{"id":"W4389436951","doi":"10.1158/2767-9764.crc-23-0361","title":"A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Sanofi; Merck KGaA; Les Laboratories Pierre Fabre; AstraZeneca; Daiichi Sankyo Europe; Eli Lilly and Company; Chugai Pharmaceutical; Servier; Göteborgs Universitet; G1 Therapeutics; Amgen","keywords":"Medicine; Oxaliplatin; Bevacizumab; Clinical endpoint; Fluorouracil; Internal medicine; Colorectal cancer; Randomized controlled trial; Adverse effect; Phases of clinical research; Bolus (digestion); Gastroenterology; Oncology; Surgery; Cancer; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009500684,0.0001798391,0.0009127497,0.0001891648,0.0005972858,0.00001859032,0.0002576842,0.00002652029,0.00003393888],"category_scores_gemma":[0.0003332082,0.0001019114,0.0001410533,0.0007253156,0.000751438,0.00004443525,0.0001952741,0.0001442571,6.790028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797246,"about_ca_system_score_gemma":0.0005560485,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.00948758,"about_ca_topic_score_gemma":0.02429865,"domain_scores_codex":[0.9979712,0.0004640191,0.000502494,0.000254372,0.0004948633,0.0003130368],"domain_scores_gemma":[0.9940667,0.004185968,0.000197056,0.0008172196,0.0006346125,0.00009842944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.947957,0.003698232,0.0003405622,0.0001132444,0.004220005,0.000005578731,0.01517696,0.00008528146,0.00008791101,0.0004742972,0.0001919209,0.02764902],"study_design_scores_gemma":[0.9580878,0.02494233,0.0005127345,0.0001230633,0.001583269,0.000001782427,0.01007005,0.001689392,0.0006152832,0.0001209396,0.002151091,0.0001022581],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774584,0.007872668,0.00000929841,0.003366049,0.00007713041,0.01059392,0.0003311318,0.00002627353,0.0002650979],"genre_scores_gemma":[0.9477274,0.02539431,0.00009906186,0.000004156172,0.00005655436,0.02631289,0.00006588954,0.000021382,0.0003183959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02973107,"threshold_uncertainty_score":0.9971083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3327243693725975,"score_gpt":0.5179726216997274,"score_spread":0.1852482523271299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}