{"id":"W4389436951","doi":"10.1158/2767-9764.crc-23-0361","title":"A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Sanofi; Merck KGaA; Les Laboratories Pierre Fabre; AstraZeneca; Daiichi Sankyo Europe; Eli Lilly and Company; Chugai Pharmaceutical; Servier; Göteborgs Universitet; G1 Therapeutics; Amgen","keywords":"Medicine; Oxaliplatin; Bevacizumab; Clinical endpoint; Fluorouracil; Internal medicine; Colorectal cancer; Randomized controlled trial; Adverse effect; Phases of clinical research; Bolus (digestion); Gastroenterology; Oncology; Surgery; Cancer; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004125545,0.002139857,0.002970906,0.0004506153,0.0005134039,0.001514411,0.001238417,0.002167527,0.007942186],"category_scores_gemma":[0.003529868,0.000827268,0.002063286,0.0003911548,0.001403269,0.001386837,0.0005444371,0.003999231,0.001412788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001219259,"about_ca_system_score_gemma":0.001780889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071378,"about_ca_topic_score_gemma":0.002180825,"domain_scores_codex":[0.9987311,0.0008307536,0.0000527648,0.0001592859,0.0000835781,0.0001425389],"domain_scores_gemma":[0.9979659,0.0005989543,0.0004921355,0.0001822265,0.0001227922,0.0006379673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9849504,0.006400764,0.0003645962,0.0002217812,0.0006107299,0.00002686456,0.00003768496,0.0002561297,0.001038058,0.000119653,0.0008470587,0.005126338],"study_design_scores_gemma":[0.9649202,0.03319161,0.0005744657,0.00001356457,0.0002230152,0.00001953616,0.00001041476,0.0003100157,0.0001494234,0.0001019077,0.0004773033,0.000008575447],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795437,0.003803112,0.000906313,0.00161783,0.001100506,0.007944155,0.001981215,0.0001494734,0.002953581],"genre_scores_gemma":[0.9701909,0.002749874,0.002789421,0.002510224,0.001072603,0.01167172,0.002607873,0.00005069597,0.006356686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007942186,"threshold_uncertainty_score":0.02656931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3327243693725975,"score_gpt":0.5179726216997274,"score_spread":0.1852482523271299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}