{"id":"W4389440549","doi":"10.1212/wnl.92.15_supplement.s12.002","title":"A Mouse Model of Meningeal Inflammation and Subpial Demyelination Identifies an IL-17-mediated Mechanism of Cortical Injury that is Inhibited by Siponimod Therapy (S12.002)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neuroscience; Inflammation; Medicine; Mechanism (biology); Psychology; Immunology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004599449,0.001746385,0.0007647918,0.001754126,0.0006134716,0.0005737558,0.0006058392,0.001421788,0.005310721],"category_scores_gemma":[0.0001008621,0.000439823,0.0008301408,0.0006811708,0.0006875323,0.0006821547,0.00030048,0.003598306,0.001256852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006581707,"about_ca_system_score_gemma":0.0008495415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432202,"about_ca_topic_score_gemma":0.00353113,"domain_scores_codex":[0.9995973,0.00005188522,0.00003956098,0.00007326961,0.0001083793,0.0001296239],"domain_scores_gemma":[0.9997501,0.00001599293,0.00007341729,0.00002578249,0.00002195954,0.0001127781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001626069,0.001167344,0.0003052094,0.0001255209,0.00003300062,0.0002807994,0.00004881865,0.0001297039,0.9914997,0.0007205107,0.0005568124,0.003506618],"study_design_scores_gemma":[0.0005772808,0.006200532,0.003299769,0.00004594803,0.0001002511,0.0009243296,0.0001032447,0.001195091,0.9789364,0.0002787571,0.008319526,0.00001882368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685293,0.003544515,0.01085411,0.001345092,0.0005873824,0.0007946791,0.005307036,0.0008065648,0.008231312],"genre_scores_gemma":[0.9428593,0.004765033,0.01689559,0.0006088737,0.0001005211,0.001568037,0.003420365,0.0001171958,0.0296651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005310721,"threshold_uncertainty_score":0.01776612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650983956937994,"score_gpt":0.2311511042236422,"score_spread":0.2146412646542623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}