{"id":"W4389442055","doi":"10.1161/hypertensionaha.123.21716","title":"Endothelin System in Hypertension and Chronic Kidney Disease","year":2023,"lang":"en","type":"review","venue":"Hypertension","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; McGill University; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada","keywords":"Medicine; Kidney disease; Endothelin receptor; Internal medicine; Kidney; Disease; Endothelin 1; Endocrinology; Cardiology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004311959,0.0006070802,0.002708088,0.0007156219,0.00008199073,0.00002606862,0.0001195308,0.0004343129,0.00001528336],"category_scores_gemma":[0.000647727,0.0004223789,0.0004208867,0.0006032593,0.0000629046,0.00005852354,0.0001680457,0.000620209,0.0009875442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003969295,"about_ca_system_score_gemma":0.0007696325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008523998,"about_ca_topic_score_gemma":0.000005599161,"domain_scores_codex":[0.9972128,0.0002238278,0.0007701648,0.0008467031,0.0004030895,0.0005434056],"domain_scores_gemma":[0.9978037,0.0004318514,0.0001924293,0.0007459203,0.0000795897,0.0007465048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001403447,0.0001713297,0.00004871984,0.180529,0.0001822802,0.0106044,0.00001180703,7.765109e-7,0.0002294846,0.00007210321,0.007079613,0.8009301],"study_design_scores_gemma":[0.002156101,0.0001614346,0.00006594299,0.147155,0.002415433,0.002346111,0.00002101971,0.0009881707,0.000005604851,0.000008840776,0.8442071,0.0004691642],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003976749,0.9964678,0.00000340581,0.000105167,0.0006113975,0.001800283,0.0000729137,0.0003464472,0.0001949284],"genre_scores_gemma":[0.000569299,0.9965605,0.0000606677,0.0003758362,0.0006921411,0.0001574472,0.0002880243,0.0002108065,0.001085322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8371275,"threshold_uncertainty_score":0.9998228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0616174331131541,"score_gpt":0.3001290772652546,"score_spread":0.2385116441521005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}