{"id":"W4389445962","doi":"10.1212/wnl.96.15_supplement.4542","title":"Study Design and Baseline Characteristics in Phase 2 Studies of Elezanumab, a Potential Neurorestorative Therapy for Multiple Sclerosis (4542)","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Multiple sclerosis; Baseline (sea); Medicine; Gerontology; Psychiatry; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130511,0.0001322129,0.0002636439,0.0000549969,0.00005285215,0.000008783338,0.00007952995,0.00008142139,0.000006038933],"category_scores_gemma":[0.001081783,0.0001304844,0.00004620788,0.00007550647,0.00009654485,0.000004964696,0.00008524109,0.0001088177,5.102601e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003832322,"about_ca_system_score_gemma":0.00005802017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000121186,"about_ca_topic_score_gemma":0.00007402486,"domain_scores_codex":[0.9986774,0.0004440892,0.0002868472,0.0003758561,0.00005602735,0.000159808],"domain_scores_gemma":[0.9990833,0.0001863059,0.0001234988,0.0002257485,0.0003501862,0.0000309302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003819032,0.001343509,0.006434583,0.00001162509,0.0001254616,0.00004573779,0.0003167823,0.00009001502,0.9840968,0.000004336725,0.0002848161,0.003427289],"study_design_scores_gemma":[0.02272827,0.03266942,0.07250097,0.00002211718,0.0001133666,0.0001153984,0.0006481276,0.002998611,0.86159,0.0001303361,0.006005855,0.0004774914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991669,0.0006636432,0.006279773,0.0003029697,0.0002844172,0.0007397395,0.00005263013,0.000005907445,0.000001927858],"genre_scores_gemma":[0.9975822,0.0006467972,0.0009340053,0.0003887772,0.0001126949,0.0002514689,0.00004003899,0.00001988402,0.00002412532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1225068,"threshold_uncertainty_score":0.5321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07855116341869764,"score_gpt":0.3381628067572243,"score_spread":0.2596116433385266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}