{"id":"W4389445974","doi":"10.1212/wnl.94.15_supplement.4918","title":"Pharmacokinetic and Food Effect Assessment of XEN496 (Pediatric Formulation of Ezogabine) in Healthy Adults and Relative Bioavailability Assessment with Potiga® (Adult Formulation of Ezogabine) (4918)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Bioavailability; Medicine; Pharmacokinetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007759805,0.0003833453,0.0004460121,0.0002042581,0.000186772,0.0003135626,0.0001980431,0.0005520091,0.003592256],"category_scores_gemma":[0.0008732295,0.0002156766,0.0003921971,0.0002322429,0.0002571493,0.0004715185,0.0001480299,0.0007261636,0.0007636179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003388601,"about_ca_system_score_gemma":0.000427736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009662206,"about_ca_topic_score_gemma":0.001533737,"domain_scores_codex":[0.9996929,0.0001246641,0.00001780296,0.00005519859,0.00008129754,0.0000282638],"domain_scores_gemma":[0.9996574,0.00005392057,0.0001341229,0.00003422586,0.00005105642,0.0000694029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1509233,0.01409544,0.06321464,0.00150466,0.001603758,0.001454863,0.0006493314,0.003300966,0.4379171,0.001366985,0.009976046,0.313993],"study_design_scores_gemma":[0.0220423,0.4171968,0.3652641,0.0001387814,0.001989952,0.007100252,0.0004523795,0.006598861,0.1262531,0.0006790303,0.05213617,0.0001482832],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846442,0.004161618,0.003975471,0.0002113005,0.00004592932,0.000869317,0.00231624,0.0001660365,0.003609929],"genre_scores_gemma":[0.9888418,0.001863941,0.004389306,0.0003593933,0.0000469011,0.0003395257,0.001838977,0.00004160466,0.002278597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003592256,"threshold_uncertainty_score":0.01201731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739621627884843,"score_gpt":0.325972213000693,"score_spread":0.3085759967218446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}