{"id":"W4389446377","doi":"10.1212/wnl.96.15_supplement.4409","title":"Development of a Novel, Clinical-stage Drug for the Prevention of Migraine Based on Receptor Activity Mapping and Achievement of a Target Receptor Profile (4409)","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Migraine; Medicine; Drug development; Drug; Receptor; Stage (stratigraphy); Pharmacology; Psychology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000647952,0.0004234239,0.0003315396,0.0003396377,0.0002185967,0.0003981639,0.0005613358,0.0004890889,0.006186821],"category_scores_gemma":[0.0002832291,0.0001518247,0.0003279799,0.0001756384,0.0002786354,0.0003759122,0.0002869845,0.001084785,0.001488832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424644,"about_ca_system_score_gemma":0.0008673304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000662246,"about_ca_topic_score_gemma":0.001695298,"domain_scores_codex":[0.9998831,0.00003739041,0.000007653755,0.00001897385,0.00002741255,0.00002554765],"domain_scores_gemma":[0.9999086,0.00001229392,0.0000136039,0.000008516788,0.00002434716,0.00003265615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002627152,0.003384469,0.001375506,0.0005708247,0.00008706349,0.0004547951,0.000133021,0.001170461,0.7987203,0.007003459,0.005008963,0.179464],"study_design_scores_gemma":[0.01148255,0.0985938,0.01563597,0.0002997603,0.0003516673,0.004768327,0.0001548089,0.006844623,0.6809722,0.004214435,0.17656,0.0001218714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7845963,0.02644409,0.1035179,0.004627564,0.001201033,0.007184578,0.003365151,0.0006529438,0.0684104],"genre_scores_gemma":[0.8633915,0.01827526,0.08232467,0.002676108,0.0002796876,0.001637533,0.003254323,0.00009019952,0.02807082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006186821,"threshold_uncertainty_score":0.02069694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07854909998304652,"score_gpt":0.3499147795979426,"score_spread":0.2713656796148961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}