{"id":"W4389446556","doi":"10.1212/wnl.94.15_supplement.4641","title":"Development of Pediatric Formulations of the Potassium Channel Opener Ezogabine and the NaV1.6-Selective Sodium Channel Blocker XEN901 for the Treatment of Developmental and Epileptic Encephalopathies (4641)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Sodium channel blocker; Sodium channel; Potassium channel; Sodium; Medicine; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237825,0.000260388,0.0001916497,0.0001610929,0.0001085354,0.0002201149,0.0003474317,0.0003458037,0.004067771],"category_scores_gemma":[0.0002173759,0.000162928,0.000176457,0.0001112231,0.0001066881,0.0003346341,0.0002113392,0.0006773137,0.001182849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673694,"about_ca_system_score_gemma":0.0004094248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007938974,"about_ca_topic_score_gemma":0.001395957,"domain_scores_codex":[0.9999255,0.00001545968,0.000005269455,0.00001242317,0.00002586528,0.00001551384],"domain_scores_gemma":[0.9999501,0.000004215253,0.00001382824,0.000003574363,0.00001490096,0.00001348667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001315365,0.0005240979,0.0004246646,0.0004403048,0.00007328684,0.0003832511,0.0001002512,0.0007183957,0.8598864,0.002525155,0.005545033,0.1280638],"study_design_scores_gemma":[0.00156872,0.007638947,0.004481789,0.0001376844,0.0001957599,0.002656724,0.00007586026,0.002753972,0.7479202,0.0006537562,0.2318753,0.00004130828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8283612,0.02889706,0.08920292,0.001746539,0.000699778,0.003624146,0.005345744,0.00085907,0.0412636],"genre_scores_gemma":[0.8686265,0.02043871,0.08015723,0.0009153086,0.0000993775,0.001478626,0.004201749,0.0002001828,0.02388223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004067771,"threshold_uncertainty_score":0.0136081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915105797926927,"score_gpt":0.2279068384860405,"score_spread":0.2087557805067713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}