{"id":"W4389446616","doi":"10.1212/wnl.94.15_supplement.4682","title":"Assessment of Potential Pharmacokinetic and Pharmacodynamic Interactions between XEN901 (a Novel NaV1.6 Selective Sodium Channel Blocker) and Phenytoin (a non-selective NaV Blocker) in Adult Healthy Subjects (4682)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Sodium channel blocker; Pharmacology; Phenytoin; Pharmacodynamics; Pharmacokinetics; Medicine; Sodium channel; Anticonvulsant; Sodium; Chemistry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400229,0.0003251728,0.0005215287,0.0001504494,0.0002277002,0.0003012757,0.0001361533,0.0004552553,0.001263521],"category_scores_gemma":[0.000863461,0.0001642652,0.0002813058,0.0002108766,0.0001837439,0.0002282014,0.0001340132,0.0003691007,0.0002667082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209478,"about_ca_system_score_gemma":0.0003482135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361751,"about_ca_topic_score_gemma":0.002210574,"domain_scores_codex":[0.9996345,0.0001725586,0.00002791318,0.00005071638,0.00007942116,0.00003495106],"domain_scores_gemma":[0.9995978,0.0001113202,0.0001261871,0.00003264068,0.0000648953,0.00006705364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08674428,0.00535279,0.3880073,0.0008983265,0.001953116,0.002758496,0.0008891681,0.001515969,0.3537177,0.0003829549,0.001957757,0.1558221],"study_design_scores_gemma":[0.001927654,0.1150069,0.8191974,0.00003699129,0.001505496,0.004626611,0.0003837601,0.003247485,0.04643632,0.0002332839,0.007360218,0.00003786703],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99586,0.001816891,0.0008096075,0.00005395479,0.00001309574,0.0001160177,0.0002351113,0.00002332085,0.001072036],"genre_scores_gemma":[0.9967744,0.0007191498,0.0009185249,0.0001922742,0.00002887051,0.00007834327,0.0002879974,0.000006683922,0.0009936995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361751,"threshold_uncertainty_score":0.004226923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976669878302905,"score_gpt":0.3293259043786245,"score_spread":0.3095592055955954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}