{"id":"W4389446646","doi":"10.1212/wnl.94.15_supplement.4593","title":"In-vitro Profile of a Novel Long Lasting Dopamine Agonist Designed to Optimize Efficacy and Safety (4593)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Agonist; Safety profile; Medicine; Dopamine; Dopamine agonist; In vitro; Internal medicine; Adverse effect; Biology; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004493103,0.0003392285,0.0002827006,0.0002047295,0.0001789601,0.0003407508,0.0002177372,0.0003353637,0.002325166],"category_scores_gemma":[0.0002108519,0.0001319171,0.000334489,0.0001946256,0.0001508686,0.0001693095,0.0001136109,0.0005531117,0.0008739446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419872,"about_ca_system_score_gemma":0.0003049416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687702,"about_ca_topic_score_gemma":0.003328033,"domain_scores_codex":[0.999745,0.0001064278,0.00002476475,0.00002758548,0.00005699841,0.00003926109],"domain_scores_gemma":[0.9997833,0.00006848048,0.00002763431,0.00002177259,0.00006078118,0.00003804627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008889891,0.0002770466,0.0002107084,0.0001114601,0.00002439253,0.00007785908,0.0000315964,0.0004230165,0.9938216,0.00008675675,0.0003388674,0.003707565],"study_design_scores_gemma":[0.0001304042,0.009488067,0.003911061,0.00001947201,0.0001199214,0.0004509189,0.00004932668,0.001201706,0.9802069,0.00004830729,0.004360269,0.00001371124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646156,0.01710193,0.005113855,0.0004344837,0.0001438786,0.0001836383,0.003452292,0.0001158603,0.008838482],"genre_scores_gemma":[0.9840809,0.004447037,0.003440613,0.0001681753,0.00004874899,0.00005975392,0.00300414,0.00002906907,0.00472148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002325166,"threshold_uncertainty_score":0.007778466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482939461670327,"score_gpt":0.2380372749884302,"score_spread":0.223207880371727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}