{"id":"W4389448392","doi":"10.1212/wnl.96.15_supplement.2835","title":"Clinical and Epidemiological Characteristics of Patients with <i>TTR</i> Mutations and Polyneuropathy Manifestations of Hereditary Transthyretin Amyloidosis: Insights from a Genetic Testing Program (2835)","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Transthyretin; Polyneuropathy; Amyloidosis; Epidemiology; Medicine; Mutation; Genetic testing; Pathology; Genetics; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357761,0.0001900308,0.0002621191,0.0006669038,0.0003326243,0.0003283876,0.0001846321,0.0004568885,0.001667884],"category_scores_gemma":[0.001593495,0.0001236143,0.0002460019,0.000752532,0.000158374,0.0004125508,0.00028944,0.0003605179,0.0004445814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002431872,"about_ca_system_score_gemma":0.0002553059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0031481,"about_ca_topic_score_gemma":0.002498307,"domain_scores_codex":[0.9997678,0.0000544086,0.00003351946,0.0000476965,0.00004741766,0.000049193],"domain_scores_gemma":[0.9990495,0.0001610355,0.0002928242,0.00004395526,0.0001333425,0.0003193167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001507658,0.00007236598,0.9981375,0.000002774714,0.00001167493,0.0002419397,0.00003553007,0.00003326422,0.0002487855,0.00001190764,0.00008862119,0.0009647597],"study_design_scores_gemma":[0.000007022319,0.0001875522,0.9982324,0.000003021797,0.00001081885,0.00119215,0.0001038713,0.0001006313,0.00004817106,0.00002358093,0.00008771911,0.000003077385],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987339,0.00007802239,0.00005995326,0.00004878993,0.000002860147,0.000007450492,0.0003045598,0.000002424183,0.000761935],"genre_scores_gemma":[0.9992424,0.00004312253,0.00006218089,0.00003725416,0.00001000959,0.000007606703,0.000419484,0.00000119278,0.0001766344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0031481,"threshold_uncertainty_score":0.006259561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629949019734258,"score_gpt":0.2674790832898831,"score_spread":0.2511795930925405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}