{"id":"W4389449776","doi":"10.1212/wnl.94.15_supplement.4425","title":"Development of a Novel Drug for the Prevention of Migraine based on Receptor Activity Mapping and Achievement of a Target Receptor Profile (4425)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Biochemical effects in animals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Receptor; Drug; Migraine; Drug development; Chemistry; Pharmacology; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003184847,0.0003374963,0.0002509943,0.0003428517,0.0001901746,0.0002997775,0.0003882282,0.0004101553,0.00306685],"category_scores_gemma":[0.0001137654,0.0001369659,0.0002901918,0.0001368557,0.0002345718,0.0002934638,0.0002345172,0.0007664316,0.0009159654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002354129,"about_ca_system_score_gemma":0.0006085096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006745206,"about_ca_topic_score_gemma":0.001463487,"domain_scores_codex":[0.9999235,0.00001599107,0.000005378953,0.00001575766,0.00001898501,0.00002048758],"domain_scores_gemma":[0.9999614,0.000004619644,0.000006446473,0.000004155445,0.000008240361,0.00001519297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000293619,0.0005325623,0.0003007282,0.000163928,0.00003146029,0.0001547278,0.00004404051,0.0005461025,0.9487285,0.004029925,0.0007186451,0.0444558],"study_design_scores_gemma":[0.0009384367,0.01423714,0.003941186,0.00007489668,0.0001445791,0.0010328,0.00005587314,0.003751329,0.9054399,0.001560406,0.06877761,0.00004595481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7906417,0.01888158,0.145886,0.002128765,0.0006342656,0.00225565,0.001284579,0.0005690264,0.03771843],"genre_scores_gemma":[0.8698829,0.01183739,0.09311296,0.001201607,0.0001145305,0.0008149857,0.001178052,0.00004547051,0.02181208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306685,"threshold_uncertainty_score":0.01025957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03590066269095373,"score_gpt":0.2803238848677204,"score_spread":0.2444232221767667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}