{"id":"W4389449957","doi":"10.1212/wnl.94.15_supplement.4295","title":"APOE-ɛ4, White Matter Hyperintensities, and Cognition in Alzheimer and Lewy Body Dementia (4295)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Eisai; University of Toronto; Alzheimer's Society; Servier; Sunnybrook Research Institute; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Fondation Brain Canada; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Hyperintensity; Dementia; Lewy body; Cognition; White matter; Psychology; Medicine; Dementia with Lewy bodies; Neuroscience; Internal medicine; Magnetic resonance imaging; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009782872,0.0002855522,0.0002228883,0.0003021611,0.0002727794,0.0003905257,0.0001909522,0.00034035,0.002019881],"category_scores_gemma":[0.0007491098,0.0001017867,0.0002738658,0.0003339894,0.000126252,0.0001989876,0.00016605,0.0002892053,0.0003353022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889016,"about_ca_system_score_gemma":0.0003560864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005305495,"about_ca_topic_score_gemma":0.009395701,"domain_scores_codex":[0.9998785,0.00003404479,0.00001452521,0.00001426984,0.00003202851,0.00002655282],"domain_scores_gemma":[0.9996846,0.00005817354,0.00008616765,0.00001582965,0.00005055941,0.0001048106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0143783,0.003927027,0.9353225,0.0002057219,0.0008150623,0.0007576266,0.0002638035,0.0001594387,0.007312124,0.0004009682,0.001432595,0.0350249],"study_design_scores_gemma":[0.0001139453,0.001511191,0.9964462,0.00001878351,0.0001419636,0.0002269256,0.0000632928,0.0001069003,0.0006263117,0.0001203696,0.0006210245,0.000003166101],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969128,0.001344229,0.00004771794,0.0001040156,0.00002424083,0.0000143318,0.0001937973,0.000002527719,0.001356359],"genre_scores_gemma":[0.996361,0.0004551252,0.0001979064,0.0001589207,0.00002378615,0.0000115926,0.0004388585,0.000001172516,0.002351714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005305495,"threshold_uncertainty_score":0.01054925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04222728978661964,"score_gpt":0.2415625813234172,"score_spread":0.1993352915367975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}