{"id":"W4389452254","doi":"10.1016/j.isci.2023.108671","title":"Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College; McGill University; Montreal Neurological Institute and Hospital","funders":"Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Universidade Federal do Rio Grande do Sul; Instituto Serrapilheira; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Academy of Neuropsychology; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Agricultural Research Division, Institute of Agriculture and Natural Resources; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Alzheimer-Forskningsfonden; Novo Nordisk; National Institute on Aging; Alzheimer's Association","keywords":"Transcriptome; Genetically modified mouse; Humanized mouse; Biology; Hippocampal formation; TREM2; Transgene; Presenilin; Alzheimer's disease; Disease; Gene; Computational biology; Neuroscience; Genetics; Medicine; Gene expression; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004609316,0.0003103666,0.0003105853,0.001195266,0.0003091596,0.0004590275,0.0001887726,0.0002809523,0.0008493396],"category_scores_gemma":[0.0003431567,0.0001337661,0.0003852966,0.0008564244,0.0003209301,0.0002929466,0.0006062961,0.0003248481,0.000202721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532836,"about_ca_system_score_gemma":0.0002546845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007650115,"about_ca_topic_score_gemma":0.001814186,"domain_scores_codex":[0.9997126,0.00003589268,0.00002215943,0.0001279618,0.00006320134,0.00003810647],"domain_scores_gemma":[0.9997717,0.00003699179,0.00008578518,0.00003127243,0.00004342791,0.00003094871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004529297,0.00004706686,0.0167759,0.0003294738,0.0002108753,0.0002071785,0.0001799889,0.000236125,0.9712895,0.0004466827,0.0003032986,0.009520979],"study_design_scores_gemma":[0.00004193181,0.0006100615,0.8135031,0.0001506638,0.0006944938,0.003126705,0.0005631798,0.002115384,0.1585063,0.002477576,0.01815443,0.00005620029],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820758,0.005670493,0.005891976,0.0001043531,0.00005039935,0.00003003118,0.004785878,0.00008977042,0.001301504],"genre_scores_gemma":[0.9765668,0.004003234,0.00752614,0.0002989992,0.00003556304,0.0001290921,0.0102215,0.00005850134,0.001160262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195266,"threshold_uncertainty_score":0.002841294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1295847820675478,"score_gpt":0.4003142719201978,"score_spread":0.2707294898526499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}