{"id":"W4389455354","doi":"10.1016/j.cryobiol.2023.104612","title":"Simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotectants","year":2023,"lang":"en","type":"article","venue":"Cryobiology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institutes of Health","keywords":"Cryoprotectant; Toxicity; Membrane permeability; Permeability (electromagnetism); Chemistry; Membrane; Chromatography; Biochemistry; Biology; Cryopreservation; Cell biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003691285,0.0005588623,0.0004442034,0.000276526,0.0002307248,0.0003301404,0.0002669605,0.0004618508,0.0009036689],"category_scores_gemma":[0.0004500485,0.0001758931,0.0003311991,0.0002527799,0.0001853178,0.0006328332,0.0003215073,0.000809514,0.0002084506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003155623,"about_ca_system_score_gemma":0.0003439893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004673478,"about_ca_topic_score_gemma":0.0007380747,"domain_scores_codex":[0.9998059,0.00003472321,0.00001182365,0.00003720683,0.00006772648,0.00004267387],"domain_scores_gemma":[0.9997858,0.00006103633,0.00004245609,0.00001609261,0.00007040934,0.00002413172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004984048,0.00001999021,0.00011334,0.00003465554,0.000005882926,0.00001558072,0.000007151847,0.00006661498,0.9981658,0.00005849954,0.0000195137,0.001443173],"study_design_scores_gemma":[0.000005289564,0.0002679907,0.001060688,0.000005731329,0.00001561471,0.00007407245,0.00001724143,0.0006355111,0.9971486,0.00007057245,0.0006942204,0.00000459695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444664,0.007678281,0.04289275,0.0003934723,0.00007049092,0.0002299752,0.0007571927,0.000137568,0.003373868],"genre_scores_gemma":[0.975998,0.004555866,0.01621923,0.0001657251,0.00001612243,0.0001387334,0.00068756,0.00002291304,0.002195826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009036689,"threshold_uncertainty_score":0.003023088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04048380179843446,"score_gpt":0.3124440651416331,"score_spread":0.2719602633431987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}