{"id":"W4389455899","doi":"10.1182/blood-2023-191921","title":"Ibrutinib Combined with Venetoclax in Patients with Relapsed/Refractory Mantle Cell Lymphoma: Primary Analysis Results from the Randomized Phase 3 Sympatico Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Medicine; Ibrutinib; Venetoclax; Mantle cell lymphoma; Internal medicine; Tumor lysis syndrome; Oncology; Bendamustine; Ven; Phases of clinical research; Neutropenia; Febrile neutropenia; Clinical endpoint; Tolerability; Rituximab; Clinical trial; Lymphoma; Chronic lymphocytic leukemia; Adverse effect; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003628887,0.001520304,0.002620664,0.000421843,0.000383035,0.001299344,0.0008489264,0.0009386771,0.004959741],"category_scores_gemma":[0.001856988,0.0006058678,0.00381839,0.0006847539,0.0007381457,0.0009178494,0.0005528353,0.002347113,0.0008070444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001103946,"about_ca_system_score_gemma":0.001564933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009749593,"about_ca_topic_score_gemma":0.003014835,"domain_scores_codex":[0.9988279,0.000716728,0.00006282644,0.0001740934,0.00008970578,0.0001287541],"domain_scores_gemma":[0.9989033,0.0002610185,0.0002997342,0.0001242984,0.00009353698,0.0003181311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9646606,0.004591875,0.003349401,0.0007046275,0.003753844,0.00003892276,0.00005141569,0.0006509394,0.003303367,0.00008827453,0.001959278,0.01684739],"study_design_scores_gemma":[0.8962151,0.07922246,0.01618848,0.00007642257,0.004627031,0.00008550046,0.00003935128,0.0006550142,0.0006723747,0.0002258607,0.001963845,0.00002862694],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789252,0.009402656,0.000757184,0.0007401498,0.000337362,0.002370013,0.004491278,0.0001462834,0.002829858],"genre_scores_gemma":[0.9849187,0.003081483,0.001191113,0.00107571,0.0003904224,0.002538431,0.005321254,0.00005256436,0.001430278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004959741,"threshold_uncertainty_score":0.01919156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087221513785876,"score_gpt":0.2567697260689992,"score_spread":0.2458975109311404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}