{"id":"W4389460532","doi":"10.1212/wnl.96.15_supplement.4465","title":"In Vitro Profile of a Novel Long Lasting Dopamine Agonist Designed to Optimize Efficacy and Safety (4465)","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Agonist; Dopamine; In vitro; Pharmacology; Dopamine agonist; Chemistry; Medicine; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005219509,0.000371016,0.0002857758,0.0002471865,0.000200888,0.0003749802,0.0002082457,0.0003642517,0.002498732],"category_scores_gemma":[0.0002172513,0.0001376947,0.0003168366,0.0002151783,0.0001635211,0.0002090594,0.0001297196,0.0005365816,0.0007937257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272591,"about_ca_system_score_gemma":0.0003488546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160303,"about_ca_topic_score_gemma":0.002764354,"domain_scores_codex":[0.9997289,0.0001095331,0.0000253625,0.00002982218,0.00006163528,0.00004474117],"domain_scores_gemma":[0.9997724,0.00007015136,0.00002987951,0.00002141322,0.00006486139,0.00004136515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009863096,0.0003220337,0.0002282703,0.000141392,0.00002368169,0.0001044833,0.00004110572,0.0003182051,0.9934035,0.00009777772,0.0003300383,0.004003189],"study_design_scores_gemma":[0.0001458929,0.01349204,0.003921745,0.00002545561,0.0001147121,0.0005134401,0.00007046682,0.001063021,0.9760695,0.00005053013,0.004519814,0.00001325275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585152,0.0218199,0.005832386,0.0005250499,0.0001854283,0.0001954904,0.00229475,0.000106418,0.01052528],"genre_scores_gemma":[0.9811064,0.006000128,0.004100365,0.0002185286,0.00007145594,0.00006045723,0.002619489,0.0000269096,0.005796305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498732,"threshold_uncertainty_score":0.008359134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258682133987332,"score_gpt":0.2601926858162359,"score_spread":0.2476058644763626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}