{"id":"W4389460747","doi":"10.1212/wnl.94.15_supplement.1592","title":"Design of a Phase 2, Randomized, Double-Blind, Placebo-Controlled, 24-Week, Parallel-Group Study of the Efficacy and Safety of Losmapimod in Treating Subjects with Facioscapulohumeral Muscular Dystrophy (FSHD): ReDUX4 (1592)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; McGill University","funders":"","keywords":"Facioscapulohumeral muscular dystrophy; Placebo; Double blind; Muscular dystrophy; Medicine; Placebo group; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004523031,0.004319905,0.005851971,0.00110994,0.001446236,0.001730073,0.00201699,0.004576346,0.01450585],"category_scores_gemma":[0.003502508,0.00234142,0.001836726,0.0006338488,0.002875009,0.002208123,0.0008193303,0.005214829,0.003076142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001180461,"about_ca_system_score_gemma":0.003408631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008587075,"about_ca_topic_score_gemma":0.002069388,"domain_scores_codex":[0.9974993,0.001041887,0.0001605589,0.0005989851,0.0002458515,0.0004534182],"domain_scores_gemma":[0.9978592,0.0004259696,0.0003979359,0.0002227456,0.0002680145,0.0008262445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9598787,0.02912786,0.00031873,0.0002838531,0.0003095956,0.00002900077,0.00003633961,0.0003018901,0.003154021,0.00013009,0.0006460001,0.005783782],"study_design_scores_gemma":[0.9213753,0.07668653,0.0005171355,0.00001020114,0.0001343795,0.000008649292,0.000009317929,0.000197281,0.0003454153,0.0001328492,0.0005677429,0.00001522977],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8014362,0.002891961,0.005629447,0.001554385,0.002824502,0.1732276,0.004250393,0.0007251822,0.007460352],"genre_scores_gemma":[0.6907873,0.002256162,0.01484238,0.005947803,0.002490491,0.2663524,0.002322411,0.0001494634,0.01485158],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01450585,"threshold_uncertainty_score":0.04852694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904755595678833,"score_gpt":0.2515489811614238,"score_spread":0.2325014252046355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}