{"id":"W4389461145","doi":"10.1212/wnl.94.15_supplement.4840","title":"Relative bioavailability, pharmacokinetic and food effect assessment of two immediate-release formulations of the NaV1.6-selective sodium channel blocker XEN901: Pediatric Granules and Adult Tablets (4840)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Bioavailability; Pharmacokinetics; Pharmacology; Chemistry; Sodium channel blocker; Sodium channel; Sodium; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009925219,0.0002663821,0.0004359307,0.0002542657,0.0001121404,0.0004227395,0.0002499276,0.0004342785,0.001888081],"category_scores_gemma":[0.001554557,0.0002143361,0.0003279308,0.0002576802,0.0002256651,0.0004839701,0.000160495,0.0006652894,0.0003554366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852505,"about_ca_system_score_gemma":0.0003086322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005646747,"about_ca_topic_score_gemma":0.000541718,"domain_scores_codex":[0.9995704,0.0001709296,0.00003179778,0.00007517959,0.000121086,0.00003052831],"domain_scores_gemma":[0.9993735,0.0001566164,0.0002753192,0.00004722902,0.00007537797,0.00007196746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.124267,0.006280156,0.00888956,0.001074824,0.0005927268,0.000630869,0.0005845127,0.001360973,0.6794426,0.0006136809,0.001452326,0.1748107],"study_design_scores_gemma":[0.01790938,0.3683138,0.1173503,0.0001295522,0.002003889,0.004754893,0.0006831727,0.0101864,0.4587224,0.0003434713,0.01938781,0.0002148329],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943415,0.002578794,0.001495712,0.00006686587,0.00003651111,0.0002063556,0.0003317444,0.00004274725,0.0008998087],"genre_scores_gemma":[0.993193,0.001516584,0.003304849,0.0001033663,0.00003502287,0.000144361,0.0003428867,0.00002337821,0.001336618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888081,"threshold_uncertainty_score":0.006316185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02664691395922273,"score_gpt":0.3329384531795426,"score_spread":0.3062915392203199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}