{"id":"W4389464500","doi":"10.1212/wnl.92.15_supplement.s56.004","title":"Efficacy and Safety of the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib (M2951) in Patients with Relapsing Multiple Sclerosis over 48 Weeks: a Randomized, Placebo-Controlled, Phase 2 Study (S56.004)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; NeuroRx Research (Canada); University of Toronto","funders":"","keywords":"Placebo; Medicine; Randomized controlled trial; Tyrosine-kinase inhibitor; Internal medicine; Multiple sclerosis; Psychiatry; Alternative medicine; Pathology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347415,0.001084344,0.001914538,0.0003426843,0.0003303114,0.0005907194,0.0006319405,0.001434413,0.004130216],"category_scores_gemma":[0.001153236,0.000518039,0.001290417,0.0002707658,0.000743817,0.001005311,0.0002843569,0.002387329,0.0007542817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005363262,"about_ca_system_score_gemma":0.000659263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006808634,"about_ca_topic_score_gemma":0.0013791,"domain_scores_codex":[0.9994948,0.0002626718,0.00003727544,0.00008790512,0.00004380758,0.0000734402],"domain_scores_gemma":[0.9993964,0.0001366271,0.0001645844,0.00004579036,0.00003963917,0.0002169494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9122517,0.01303795,0.001631517,0.0006171884,0.001014348,0.00009900337,0.00006889871,0.0006394191,0.01695285,0.0001030842,0.001129103,0.05245504],"study_design_scores_gemma":[0.8101317,0.1766376,0.009598396,0.00003846372,0.0004184671,0.0001232902,0.00002310412,0.0005181393,0.001527526,0.0001205096,0.0008386504,0.00002423162],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909927,0.004283276,0.0003328108,0.0003560885,0.0001632834,0.001031463,0.0007323707,0.00007385699,0.002034149],"genre_scores_gemma":[0.9937569,0.001822971,0.0007362459,0.0004957183,0.000197576,0.0006957782,0.001012468,0.00001474054,0.001267747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004130216,"threshold_uncertainty_score":0.01381695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151024199126059,"score_gpt":0.259260521617082,"score_spread":0.2477502796258214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}