{"id":"W4389464500","doi":"10.1212/wnl.92.15_supplement.s56.004","title":"Efficacy and Safety of the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib (M2951) in Patients with Relapsing Multiple Sclerosis over 48 Weeks: a Randomized, Placebo-Controlled, Phase 2 Study (S56.004)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; NeuroRx Research (Canada); University of Toronto","funders":"","keywords":"Placebo; Medicine; Randomized controlled trial; Tyrosine-kinase inhibitor; Internal medicine; Multiple sclerosis; Psychiatry; Alternative medicine; Pathology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001144077,0.0003191634,0.001485826,0.0002503554,0.00008453833,0.00001741984,0.000214088,0.0001968367,0.0001302874],"category_scores_gemma":[0.001719658,0.0001932243,0.0001489078,0.0004142455,0.0004505183,0.00009313252,0.0002820736,0.0006500379,0.00001823326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007141309,"about_ca_system_score_gemma":0.001009404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000811815,"about_ca_topic_score_gemma":0.0001828431,"domain_scores_codex":[0.9962785,0.001010141,0.0008236957,0.0006577267,0.0006784903,0.0005514249],"domain_scores_gemma":[0.9963333,0.002243032,0.0003111934,0.0008057439,0.0001556999,0.0001510303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8499812,0.002744599,0.1443835,0.0000668404,0.0001806629,0.00004361454,0.0006427665,0.000082409,0.001097613,0.00001259852,0.00007968335,0.000684491],"study_design_scores_gemma":[0.887104,0.004677533,0.1016368,0.0001782151,0.0002288194,0.0000201034,0.00003528429,0.005612744,0.0002645476,0.000003666483,0.00009426642,0.0001440239],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895977,0.0001936331,0.000004120906,0.0004309536,0.0003580376,0.009137622,0.00001465672,0.00003110485,0.0002321413],"genre_scores_gemma":[0.9991137,0.00002613909,0.00002454809,0.0004050129,0.00006783464,0.0001444189,0.000009730766,0.00005785322,0.0001507333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04274674,"threshold_uncertainty_score":0.7879458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151024199126059,"score_gpt":0.259260521617082,"score_spread":0.2477502796258214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}