{"id":"W4389464841","doi":"10.1212/wnl.92.15_supplement.p3.2-037","title":"Improved Clinical and MRI Disease Activity Outcomes, Including Slowing of Brain Volume Loss, in Alemtuzumab-Treated RRMS Patients: 8-Year Follow-up of CARE-MS I (TOPAZ Study) (P3.2-037)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada); Montreal Neurological Institute and Hospital","funders":"","keywords":"Alemtuzumab; Topaz; Medicine; Multiple sclerosis; Nuclear medicine; Internal medicine; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001570929,0.0005759729,0.0009583556,0.000434931,0.0003629971,0.0006014475,0.0004805915,0.0006501696,0.0008760836],"category_scores_gemma":[0.001319608,0.0001909903,0.0008108991,0.0004341065,0.0002421479,0.0006068922,0.0003773486,0.0008021811,0.0002243965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004044574,"about_ca_system_score_gemma":0.0004317472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002414079,"about_ca_topic_score_gemma":0.003428683,"domain_scores_codex":[0.9996221,0.0001444894,0.00003297057,0.00007189926,0.0000610784,0.00006732683],"domain_scores_gemma":[0.9991667,0.00008051178,0.0003470904,0.00006746105,0.000132362,0.0002059608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2526802,0.005970545,0.6429366,0.0005981713,0.007045599,0.0002873469,0.0003941584,0.0008464118,0.01394995,0.00009970291,0.003002071,0.07218929],"study_design_scores_gemma":[0.01123262,0.03774854,0.9453673,0.00004747434,0.002269653,0.0002070948,0.00008104713,0.000350209,0.001678901,0.00008719975,0.0009027891,0.00002716389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973929,0.001411741,0.00005079751,0.00005345587,0.00001248302,0.00006903382,0.000513583,0.00001130105,0.0004846263],"genre_scores_gemma":[0.9976052,0.0004117906,0.0001954498,0.0001073282,0.00004427833,0.00005646599,0.001235323,0.000004090176,0.000340073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414079,"threshold_uncertainty_score":0.008307934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742487141834817,"score_gpt":0.350606514903647,"score_spread":0.3131816434852988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}