{"id":"W4389464889","doi":"10.1212/wnl.92.15_supplement.p3.2-023","title":"EDSS and Timed 25 Foot Walk Correlate with Spinal Cord Areas: Baseline Results from the SPI2 Clinical Trial of MD-1003 (high-dose biotin) in Progressive Multiple Sclerosis (P3.2-023)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Spinal cord; Multiple sclerosis; Foot (prosody); Clinical trial; Surgery; Internal medicine; Psychiatry; Art","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347481,0.0007349892,0.0007841883,0.0001921857,0.0002169717,0.0004640217,0.0004161455,0.000934134,0.002386597],"category_scores_gemma":[0.00126702,0.000219945,0.0004645946,0.0002411599,0.0004049265,0.00039706,0.000224417,0.001197905,0.000480056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003871331,"about_ca_system_score_gemma":0.0005106153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067956,"about_ca_topic_score_gemma":0.001879197,"domain_scores_codex":[0.9996712,0.0001608029,0.00001892948,0.00005083688,0.00004296236,0.00005523251],"domain_scores_gemma":[0.999222,0.0001322704,0.000237921,0.00004443985,0.00006690249,0.0002963622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7849396,0.0172272,0.1065131,0.0004273407,0.002481972,0.0002602861,0.0001598553,0.001018387,0.03957577,0.0001023787,0.002284751,0.04500939],"study_design_scores_gemma":[0.1290282,0.2423864,0.6173655,0.00004159327,0.001327888,0.0005610794,0.00008398628,0.00146761,0.005741824,0.0002745303,0.001674285,0.00004704424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977173,0.0008748213,0.0001080444,0.0001161306,0.00001514004,0.0001312563,0.00052289,0.00001609108,0.0004983431],"genre_scores_gemma":[0.9977952,0.0002180252,0.0001962454,0.000147358,0.00003217758,0.0001257594,0.0008697712,0.000004371376,0.0006110551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002386597,"threshold_uncertainty_score":0.007983983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882140224202248,"score_gpt":0.2792971532129752,"score_spread":0.2504757509709527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}