{"id":"W4389464889","doi":"10.1212/wnl.92.15_supplement.p3.2-023","title":"EDSS and Timed 25 Foot Walk Correlate with Spinal Cord Areas: Baseline Results from the SPI2 Clinical Trial of MD-1003 (high-dose biotin) in Progressive Multiple Sclerosis (P3.2-023)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Spinal cord; Multiple sclerosis; Foot (prosody); Clinical trial; Surgery; Internal medicine; Psychiatry; Art","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005062133,0.0002314608,0.0004374474,0.00003973611,0.00006271218,0.00001084201,0.0002249831,0.0005139924,0.00001067657],"category_scores_gemma":[0.0004935527,0.0001450125,0.00009172438,0.0001208869,0.0005166783,0.000003646355,0.0002304107,0.0005105746,0.00001127838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003469346,"about_ca_system_score_gemma":0.00006129273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002919792,"about_ca_topic_score_gemma":0.0003001165,"domain_scores_codex":[0.9978119,0.0004665601,0.0006085814,0.0006737624,0.0001309026,0.0003082506],"domain_scores_gemma":[0.9986561,0.0003589551,0.0003498232,0.0004706783,0.0000922683,0.00007218503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8197001,0.001091339,0.1173718,0.0000298483,0.0005645399,0.000101724,0.0001279962,0.00005338181,0.03159028,0.00003538604,0.002880514,0.02645312],"study_design_scores_gemma":[0.1887676,0.07910313,0.7091295,0.0001955619,0.0002774897,0.00007840985,0.0001036201,0.0009328442,0.009773465,0.00006044787,0.01090211,0.0006758838],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947678,0.00144472,0.00001050425,0.001978962,0.0007924295,0.0007811897,0.00009786548,0.00001204144,0.0001144985],"genre_scores_gemma":[0.9969356,0.001525402,0.0002231819,0.000806163,0.0002858692,0.00001730877,0.0001142746,0.0000232222,0.00006895335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6309325,"threshold_uncertainty_score":0.5913439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882140224202248,"score_gpt":0.2792971532129752,"score_spread":0.2504757509709527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}