{"id":"W4389467584","doi":"10.1212/wnl.82.10_supplement.i7-1.001","title":"S1P Receptor Modulation by Fingolimod Promotes Human Oligodendrocyte Progenitor Cell Differentiation through Cell-Autonomous and Non-Cell Autonomous Mechanisms via ERK1/2 and p38MAPK Activation (I7-1.001)","year":2014,"lang":"en","type":"article","venue":"Neurology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Cell biology; Progenitor cell; Fingolimod; Cell; Cellular differentiation; Oligodendrocyte; Chemistry; Modulation (music); Receptor; Neuroscience; Stem cell; Biology; Multiple sclerosis; Immunology; Myelin; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009406361,0.0002909587,0.0002051246,0.0001291963,0.0001111275,0.0001883408,0.0001335179,0.0001808666,0.001889176],"category_scores_gemma":[0.00005971627,0.00009659736,0.0003501292,0.0001072409,0.0001241525,0.0001219895,0.0001123795,0.000332813,0.0004948584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159393,"about_ca_system_score_gemma":0.0002496811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006486084,"about_ca_topic_score_gemma":0.0009646427,"domain_scores_codex":[0.9999318,0.000007751402,0.000007181232,0.00001198835,0.00001580832,0.00002544975],"domain_scores_gemma":[0.9999802,0.000003095595,0.000006493482,0.000002081636,0.000002712789,0.000005422689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003783024,0.00008286021,0.0001002539,0.00008148764,0.000005863916,0.0000914256,0.00001858599,0.00005650829,0.996586,0.00004771967,0.0001001891,0.002450859],"study_design_scores_gemma":[0.0000694121,0.0007503044,0.003980859,0.000007954863,0.00002574531,0.0002946642,0.00002634835,0.000507482,0.9915754,0.00002719187,0.0027309,0.000003640328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951047,0.001928191,0.0008466232,0.00008539907,0.00002381759,0.00003217388,0.0003992148,0.00005059564,0.001529308],"genre_scores_gemma":[0.9915827,0.002831621,0.001848245,0.00005198685,0.00002220184,0.00008813415,0.0007644653,0.00001088609,0.002799881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889176,"threshold_uncertainty_score":0.00631988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599728658043963,"score_gpt":0.2021316319037573,"score_spread":0.1961343453233177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}