{"id":"W4389473212","doi":"10.1101/2023.12.06.570390","title":"A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Stand Up To Cancer; National Cancer Institute; Cancer Research UK; National Institutes of Health; Mark Foundation For Cancer Research; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Neuroblastoma; Proteogenomics; Computational biology; Cancer research; Biology; Computer science; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009656356,0.0002195848,0.0002126853,0.0004612788,0.0001599774,0.0002355009,0.00008087241,0.0001513414,0.0005462083],"category_scores_gemma":[0.0001470789,0.00008820193,0.0002365437,0.0004013733,0.0001081934,0.0001511304,0.0002261463,0.0001890201,0.0001506635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691469,"about_ca_system_score_gemma":0.0002046729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001437711,"about_ca_topic_score_gemma":0.002379001,"domain_scores_codex":[0.9999453,0.000003704099,0.000003233491,0.00001776573,0.00001813943,0.00001190418],"domain_scores_gemma":[0.9999509,0.000006826654,0.00001651289,0.000004227607,0.00001214833,0.000009331305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000159151,0.00001156427,0.008088302,0.000052502,0.00002125022,0.0001120457,0.00003441839,0.0002017219,0.9869366,0.00005925248,0.00008753659,0.00423556],"study_design_scores_gemma":[0.00001668381,0.0002651743,0.5103617,0.0000233331,0.0001684551,0.002086968,0.0003021152,0.008623699,0.4719119,0.0004198148,0.005790298,0.00002981259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946018,0.0008197314,0.002070237,0.00005845974,0.000005914358,0.0000162835,0.001793748,0.00003763076,0.0005961304],"genre_scores_gemma":[0.9900168,0.001204175,0.003281602,0.00006883263,0.000004978835,0.00002461335,0.003973366,0.00001834458,0.001407364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437711,"threshold_uncertainty_score":0.002858698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066412030026291,"score_gpt":0.2896485250059799,"score_spread":0.258984404705717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}