{"id":"W4389475006","doi":"10.2337/db23-0483","title":"RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Human Islet Research Network; National Institutes of Health; National Science Foundation","keywords":"Biology; Islet; Gene; Gene expression; Phenotype; Cell biology; Pancreatic islets; Secretion; Cell; Transcription factor; Regulation of gene expression; Endocrinology; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477957,0.0002080598,0.000264016,0.0002073965,0.000158793,0.0003906843,0.0001782929,0.0001825966,0.001785639],"category_scores_gemma":[0.0002049569,0.0001214581,0.0002026636,0.0001736047,0.0001661839,0.0001731871,0.0002238249,0.0003359681,0.0007759819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001158643,"about_ca_system_score_gemma":0.0001190453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002872668,"about_ca_topic_score_gemma":0.0003173457,"domain_scores_codex":[0.9998707,0.00001484762,0.00001442253,0.00004272734,0.00003410408,0.00002327929],"domain_scores_gemma":[0.9998209,0.0000298247,0.00003423465,0.00004779045,0.00002192416,0.00004542055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302924,0.00001123205,0.0002745231,0.00001344426,0.000003194272,0.00003087805,0.00002119675,0.00003670012,0.9974672,0.00005456741,0.00002429288,0.001932458],"study_design_scores_gemma":[0.00002246506,0.0002657456,0.01183051,0.000007793761,0.00001657298,0.000475115,0.00004520185,0.0007180169,0.9805771,0.00008261885,0.005953078,0.000005841496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915292,0.001416467,0.004428133,0.00006326376,0.00002484109,0.00001878897,0.0007733935,0.0001520321,0.001593876],"genre_scores_gemma":[0.9906545,0.0007772484,0.003381675,0.00005511729,0.00001446546,0.0000254163,0.001643402,0.00009959924,0.003348623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001785639,"threshold_uncertainty_score":0.005973518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327682027893158,"score_gpt":0.2440817974723543,"score_spread":0.2308049771934227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}