{"id":"W4389477747","doi":"10.1016/j.crmeth.2023.100663","title":"AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells","year":2023,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Héma-Québec; University of Ottawa; University of Toronto; Canadian Blood Services","funders":"Health Canada; Government of Canada; Canadian Blood Services; Australian Government","keywords":"Progenitor cell; Haematopoiesis; Stem cell; Cell biology; GAS6; Biology; Hematopoietic stem cell; DNA demethylation; Demethylation; Cancer research; Chemistry; Signal transduction; Biochemistry; DNA methylation; Receptor tyrosine kinase; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002033495,0.000308767,0.0006541794,0.0003165601,0.0001693992,0.00002113705,0.0001615026,0.0003272667,0.00008201342],"category_scores_gemma":[0.00002921831,0.0002495228,0.0001441675,0.0008238615,0.0001052242,0.0001280188,0.0001297999,0.0002067516,0.0001319291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006091441,"about_ca_system_score_gemma":0.0001463004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002688877,"about_ca_topic_score_gemma":0.000001493936,"domain_scores_codex":[0.9971039,0.0007381581,0.00096388,0.0006030492,0.0001348122,0.000456213],"domain_scores_gemma":[0.997843,0.0003475817,0.0007833759,0.0007507444,0.0002086178,0.00006671259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008814205,0.00009219133,0.0002637779,0.0001843381,0.00005540837,0.00003788176,0.001258943,0.0003265245,0.9706072,0.000007277806,0.0005611573,0.02651714],"study_design_scores_gemma":[0.0004651192,0.0003114385,0.002061924,0.0001139571,0.00009409551,0.00006419967,0.0004391618,0.0000766014,0.9840059,0.00004600016,0.01203825,0.0002833316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838483,0.001580533,0.0117927,0.00004644933,0.0009329908,0.0007553935,0.000007552923,0.0002110923,0.0008249325],"genre_scores_gemma":[0.9832079,0.00009415039,0.007842633,0.00002291577,0.00001853761,0.00006418937,0.0001209685,0.00005946857,0.008569257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02623381,"threshold_uncertainty_score":0.9999957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132437341019311,"score_gpt":0.2845677039231985,"score_spread":0.2632433305130054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}