{"id":"W4389477747","doi":"10.1016/j.crmeth.2023.100663","title":"AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells","year":2023,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Héma-Québec; University of Ottawa; University of Toronto; Canadian Blood Services","funders":"Health Canada; Government of Canada; Canadian Blood Services; Australian Government","keywords":"Progenitor cell; Haematopoiesis; Stem cell; Cell biology; GAS6; Biology; Hematopoietic stem cell; DNA demethylation; Demethylation; Cancer research; Chemistry; Signal transduction; Biochemistry; DNA methylation; Receptor tyrosine kinase; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875555,0.0003536562,0.0001969417,0.0002373855,0.0001378895,0.0002065118,0.0001663457,0.0002103986,0.001496923],"category_scores_gemma":[0.00008854897,0.00009750123,0.0001919923,0.0001429442,0.0001551203,0.0001661352,0.0002513413,0.0003264986,0.0002926111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443887,"about_ca_system_score_gemma":0.0001816085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002010783,"about_ca_topic_score_gemma":0.0008469925,"domain_scores_codex":[0.9998293,0.00004552939,0.00001558397,0.0000281246,0.00004949635,0.00003193391],"domain_scores_gemma":[0.9999269,0.00001857658,0.00001758681,0.0000101788,0.000007833937,0.00001875159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004212957,0.0000127747,0.0000645482,0.00001742275,0.000003012753,0.00001826927,0.000004521651,0.00009045003,0.998757,0.00003452777,0.00001979256,0.0009356419],"study_design_scores_gemma":[0.000003458134,0.0001293836,0.0003986793,0.000001303409,0.000003582049,0.00004663208,0.000004530337,0.0002274944,0.9982221,0.00001007392,0.0009515144,0.000001351414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859567,0.001776336,0.00897555,0.0001248791,0.00002551908,0.00008424024,0.0003612127,0.0001217528,0.002573943],"genre_scores_gemma":[0.98948,0.0009438446,0.006797778,0.00006144288,0.00001544829,0.00007575168,0.0004057977,0.00002561594,0.002194283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496923,"threshold_uncertainty_score":0.005007684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132437341019311,"score_gpt":0.2845677039231985,"score_spread":0.2632433305130054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}