{"id":"W4389477764","doi":"10.1016/j.medj.2023.11.002","title":"Augmentation in depression: Esketamine, a new standard?","year":2023,"lang":"no","type":"article","venue":"Med","topic":"Treatment of Major Depression","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Psychiatric Association; National Natural Science Foundation of China; Canadian Institutes of Health Research; Brain and Cognition Discovery Foundation; Canadian Cancer Society; Boehringer Ingelheim; Milken Institute; Global Alliance for Chronic Diseases","keywords":"Treatment-resistant depression; Quetiapine; Depression (economics); Nasal spray; Medicine; Randomized controlled trial; Placebo; Internal medicine; Anesthesia; Psychology; Psychiatry; Antidepressant; Pharmacology; Alternative medicine; Nasal administration; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001578811,0.00057373,0.001598336,0.0004044159,0.00044416,0.001601693,0.001055131,0.001904791,0.009993155],"category_scores_gemma":[0.001869731,0.0001838745,0.0008639108,0.0004600416,0.0009103045,0.002467874,0.0004876593,0.004475972,0.002404677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005910844,"about_ca_system_score_gemma":0.0009210224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009637328,"about_ca_topic_score_gemma":0.00433593,"domain_scores_codex":[0.9996239,0.0001257773,0.00005275187,0.00006024557,0.00007554059,0.00006173263],"domain_scores_gemma":[0.9990954,0.000309493,0.0001743079,0.00004979924,0.0001570765,0.0002138015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01135588,0.001026386,0.001864249,0.001992632,0.0002950786,0.0005575585,0.0001140369,0.0003851338,0.003259978,0.009438115,0.06996247,0.8997484],"study_design_scores_gemma":[0.01928162,0.02122676,0.03055609,0.01047154,0.001613883,0.005797616,0.001229604,0.004041877,0.003429836,0.05028214,0.8516981,0.0003708937],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03825833,0.7755913,0.003390896,0.1442261,0.01192841,0.0001033813,0.0005629171,0.000310223,0.02562847],"genre_scores_gemma":[0.2176179,0.649375,0.008457605,0.07373181,0.02731504,0.0002291431,0.0006774131,0.0001193191,0.02247674],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009993155,"threshold_uncertainty_score":0.03343046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866578972167561,"score_gpt":0.3300728823483286,"score_spread":0.301407092626653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}