{"id":"W4389480834","doi":"10.1016/j.iotech.2023.100668","title":"157TiP Krascendo-170 Lung: A phase Ib/II study of divarasib + pembrolizumab ± platinum-based chemotherapy and pemetrexed in untreated KRAS G12C+ advanced non-small cell lung cancer (NSCLC)","year":2023,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Genentech; Ipsen; Sanofi; Bayer HealthCare; F. Hoffmann-La Roche; Incyte; Natera; Amgen; ViiV Healthcare; Eisai; AstraZeneca; Bristol-Myers Squibb","keywords":"Pemetrexed; Pembrolizumab; Medicine; Lung cancer; Chemotherapy; Oncology; KRAS; Internal medicine; Lung; Cancer; Cisplatin; Colorectal cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002007547,0.000490348,0.001265652,0.001614612,0.0002086425,0.000008931451,0.0002955354,0.0005732311,0.0001720492],"category_scores_gemma":[0.00009090943,0.0004429165,0.0001117543,0.002290552,0.0003301138,0.00008035707,0.000160985,0.0005237858,0.00000683182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008524255,"about_ca_system_score_gemma":0.000953555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009707676,"about_ca_topic_score_gemma":0.0009864597,"domain_scores_codex":[0.997312,0.0001031811,0.0008206383,0.0007935146,0.0002179757,0.0007526798],"domain_scores_gemma":[0.9982427,0.0002568474,0.0004174306,0.0007527781,0.0002204963,0.000109788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.00718399,0.01341579,0.5997234,0.0004642439,0.002045144,0.00116373,0.009420363,0.0003661953,0.2245388,0.0000689581,0.00120869,0.1404007],"study_design_scores_gemma":[0.4913401,0.03997913,0.291059,0.001073586,0.003881731,0.0002108718,0.01571398,0.01373458,0.1357991,0.0002356057,0.005312706,0.001659473],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989275,0.003258319,0.00005904553,0.002360654,0.0002987765,0.003485511,0.00008273472,0.0004635262,0.000716422],"genre_scores_gemma":[0.9959431,0.0008154053,0.0005769343,0.000206181,0.0000326499,0.001552734,0.0001262161,0.00009118772,0.0006555333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4841562,"threshold_uncertainty_score":0.9998022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084802645926599,"score_gpt":0.3612404445660097,"score_spread":0.3503924181067438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}