{"id":"W4389480868","doi":"10.1016/j.iotech.2023.100606","title":"134P A phase I study exploring the safety and tolerability of the small molecule PD-L1 inhibitor INCB099318 in select advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chugai Pharmaceutical; Incyte; Sierra Oncology; Da Volterra; Ipsen; Eisai; Bristol-Myers Squibb; AstraZeneca; Carrick Therapeutics; Pfizer; Dr. Falk Pharma; ViiV Healthcare","keywords":"Tolerability; Medicine; Pharmacokinetics; Internal medicine; Adverse effect; Clinical endpoint; Gastroenterology; Oncology; Pharmacology; Clinical trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001881926,0.0002500276,0.001189688,0.0005188298,0.0002671087,0.000005858295,0.0005357577,0.0003421284,0.00003529602],"category_scores_gemma":[0.001974203,0.0001589668,0.00009218289,0.00206508,0.001464526,0.0000575979,0.0008144485,0.001133853,0.00001538231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003662565,"about_ca_system_score_gemma":0.0006692944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001625408,"about_ca_topic_score_gemma":0.0006193146,"domain_scores_codex":[0.9970971,0.0005526258,0.000916168,0.0005133659,0.0002342726,0.0006864879],"domain_scores_gemma":[0.9976512,0.0008880445,0.0002372822,0.0009804043,0.0001793369,0.00006378406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004831895,0.003279988,0.7783114,0.0001308926,0.000418385,0.0004466828,0.005665003,0.00001988998,0.1382902,0.000507989,0.0001044387,0.06799319],"study_design_scores_gemma":[0.02674679,0.01580385,0.8778682,0.0002920152,0.0003717481,0.0005882822,0.02711055,0.001344609,0.04428941,0.001831214,0.003331534,0.0004217736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896411,0.0004360185,0.00001970364,0.006397722,0.0002315331,0.002335455,0.000007460004,0.0001795411,0.0007515094],"genre_scores_gemma":[0.9982367,0.0003404033,0.0001673691,0.0001396978,0.00003436988,0.0008312867,0.000004920783,0.00002837148,0.0002168655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09955678,"threshold_uncertainty_score":0.6482478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04229348806635307,"score_gpt":0.3719076108827646,"score_spread":0.3296141228164115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}