{"id":"W4389484646","doi":"10.1016/j.isci.2023.108693","title":"Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Alberta; JDRF; National Institute of Diabetes and Digestive and Kidney Diseases; Stanford Diabetes Research Center; Wellcome Trust; Juvenile Diabetes Research Foundation United States of America","keywords":"CRISPR; Genome editing; Ribonucleoprotein; Cas9; Biology; Human genome; Gene; Guide RNA; Computational biology; Electroporation; RNA; DNA; Genetics; Genome; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128302,0.000395997,0.0003832445,0.0001666056,0.0001725107,0.000562463,0.0003312382,0.0004254731,0.00138779],"category_scores_gemma":[0.0002345608,0.0002182533,0.0003190889,0.0001193933,0.0003037856,0.0001592483,0.0004107575,0.0008273248,0.0005630077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00032999,"about_ca_system_score_gemma":0.000233807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005964038,"about_ca_topic_score_gemma":0.001123856,"domain_scores_codex":[0.9997,0.00003892792,0.00002939782,0.000117319,0.0000806553,0.0000337349],"domain_scores_gemma":[0.9998462,0.00004200892,0.00002980376,0.00004305742,0.00001561484,0.00002330626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004152283,0.00001420847,0.0001303622,0.00002500352,0.000007987657,0.00007114244,0.00001705414,0.0002239334,0.9966988,0.0002757432,0.00009648677,0.002397829],"study_design_scores_gemma":[0.00000879722,0.00006535573,0.0004246541,0.000002969896,0.00001069218,0.0001763832,0.000007621554,0.001756015,0.9937411,0.00008110429,0.003719939,0.000005336022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7127402,0.001598282,0.2713127,0.0003207509,0.0002912784,0.0004898784,0.001909296,0.002510324,0.008827332],"genre_scores_gemma":[0.911122,0.0007769421,0.07868606,0.0001272265,0.00002314657,0.0002104953,0.001330132,0.0001695353,0.007554524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138779,"threshold_uncertainty_score":0.004642665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008611692295288435,"score_gpt":0.2760805612757267,"score_spread":0.2674688689804383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}