{"id":"W4389486980","doi":"10.1021/acssensors.3c01866","title":"Unlocking Pb<sup>2+</sup> Sensing Potential in a DNA G-Quadruplex via Loop Modification with Fluorescent Chalcone Surrogates","year":2023,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Lethbridge; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Guelph; University of Lethbridge","keywords":"Chalcone; G-quadruplex; Guanine; Fluorescence; Aptamer; DNA; Biosensor; Chemistry; Combinatorial chemistry; Biophysics; Stereochemistry; Biochemistry; Nucleotide; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422737,0.0002551853,0.0002465146,0.0002161733,0.000121272,0.00003826773,0.0001222329,0.0001990196,0.000001072792],"category_scores_gemma":[0.00006227634,0.00022282,0.00008865575,0.0005622694,0.0001229868,0.000008907306,0.0000884468,0.0001460502,0.00001534728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003809392,"about_ca_system_score_gemma":0.00003048102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007902557,"about_ca_topic_score_gemma":0.00008013308,"domain_scores_codex":[0.9983549,0.0001018493,0.0003004039,0.0005766122,0.0002268761,0.0004393522],"domain_scores_gemma":[0.9992028,0.00001815025,0.0001241892,0.0004377887,0.0001409485,0.00007612957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001105495,0.00004235797,0.001052686,0.00001626091,0.00006161043,0.00005770457,0.000105395,0.009353958,0.9831387,0.000006481439,0.0000965225,0.005957779],"study_design_scores_gemma":[0.0004404155,0.0001234746,0.001470769,0.0000591564,0.00004180379,0.00004949575,0.000475147,0.03710441,0.9595393,0.00005546317,0.000293728,0.0003468547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968251,0.0000496553,0.002229471,0.0004386874,0.00002784616,0.0002031053,0.000008755173,0.0001587899,0.00005861435],"genre_scores_gemma":[0.9963691,0.000200041,0.002583516,0.00007775167,0.0001501443,0.000004051861,0.0003120328,0.00004442512,0.0002588936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02775045,"threshold_uncertainty_score":0.9086335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333076135486772,"score_gpt":0.2601337566118365,"score_spread":0.2468029952569687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}