{"id":"W4389486980","doi":"10.1021/acssensors.3c01866","title":"Unlocking Pb<sup>2+</sup> Sensing Potential in a DNA G-Quadruplex via Loop Modification with Fluorescent Chalcone Surrogates","year":2023,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Lethbridge; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Guelph; University of Lethbridge","keywords":"Chalcone; G-quadruplex; Guanine; Fluorescence; Aptamer; DNA; Biosensor; Chemistry; Combinatorial chemistry; Biophysics; Stereochemistry; Biochemistry; Nucleotide; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405242,0.0002543971,0.0001856105,0.00009921004,0.00009279441,0.0002237466,0.0003330361,0.0003482937,0.0007957807],"category_scores_gemma":[0.0003176157,0.0001302267,0.0001220508,0.0001035947,0.0003612243,0.0002494569,0.0002132343,0.0003238966,0.0003939804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002879265,"about_ca_system_score_gemma":0.0001560259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002625886,"about_ca_topic_score_gemma":0.0003944528,"domain_scores_codex":[0.9998549,0.00002998938,0.00001153073,0.00004395597,0.00003552751,0.00002404049],"domain_scores_gemma":[0.9998031,0.00004783876,0.00006801808,0.00001719078,0.00003063673,0.00003318064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004596573,0.000006339904,0.00004200542,0.00001733353,0.000001734457,0.00001865825,0.00001371154,0.00009352644,0.9985327,0.0000775792,0.0000182042,0.001132189],"study_design_scores_gemma":[0.00000470715,0.00009495397,0.0001378862,8.575775e-7,0.000001845681,0.00004069962,0.000003670273,0.0005049712,0.9987811,0.00002253566,0.0004039377,0.000002615767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865317,0.0002845952,0.01161545,0.0001005849,0.00002217363,0.00003783275,0.0000764556,0.0003019751,0.001029107],"genre_scores_gemma":[0.9882817,0.000131464,0.01013582,0.0001128179,0.000006583295,0.00003247044,0.00008304199,0.00004301987,0.001173181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007957807,"threshold_uncertainty_score":0.002662182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333076135486772,"score_gpt":0.2601337566118365,"score_spread":0.2468029952569687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}