{"id":"W4389488824","doi":"10.1101/2023.12.08.570741","title":"Filamin protects myofibrils from contractile damage through changes in its mechanosensory region","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Filamin; Sarcomere; Myofibril; Actin; Cell biology; Cytoskeleton; FLNA; Contraction (grammar); Biology; Anatomy; Chemistry; Myocyte; Genetics; Biochemistry; Cell; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009598162,0.000191946,0.0001174866,0.0001774385,0.0001419415,0.0001972187,0.0002756644,0.0003644695,0.001401794],"category_scores_gemma":[0.0001101001,0.00009769276,0.0001283006,0.000059563,0.0002995184,0.000133925,0.0002459471,0.0003972869,0.0002943677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579063,"about_ca_system_score_gemma":0.00008089448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005022177,"about_ca_topic_score_gemma":0.0004631674,"domain_scores_codex":[0.9999406,0.000007011952,0.00000670562,0.00001487195,0.00001523308,0.00001558309],"domain_scores_gemma":[0.9998584,0.00002688399,0.00004614819,0.00002091963,0.00001196785,0.00003580662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004908298,0.000008525651,0.0001924923,0.000007595726,0.000002011153,0.00002422061,0.000004196399,0.00001830052,0.9993755,0.00004741058,0.000009942926,0.0002607306],"study_design_scores_gemma":[0.00001111848,0.00006989679,0.009373994,0.000004090243,0.000006742533,0.0001757735,0.00002079689,0.0003654877,0.9892211,0.00003881281,0.0007095398,0.000002640757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970921,0.000386285,0.001415962,0.00009864383,0.00001408355,0.000006980857,0.0001837858,0.00002537876,0.0007768193],"genre_scores_gemma":[0.9967991,0.000143107,0.0009745005,0.00005021741,0.000005744091,0.000007317311,0.0001935157,0.00001563027,0.001810891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401794,"threshold_uncertainty_score":0.004689455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04799491616099123,"score_gpt":0.2599920196096581,"score_spread":0.2119971034486668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}