{"id":"W4389489555","doi":"10.1182/hematology.2023000439","title":"Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease","year":2023,"lang":"en","type":"review","venue":"Hematology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Langerhans cell histiocytosis; Salvage therapy; Oncology; Internal medicine; Discontinuation; MAPK/ERK pathway; Disease; Chemotherapy; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004097648,0.0005245121,0.001637646,0.0008798476,0.0003571362,0.00190365,0.0009202881,0.001915862,0.002341714],"category_scores_gemma":[0.003686425,0.000220269,0.0008498743,0.0004906901,0.001260685,0.004178063,0.001011234,0.005293823,0.001399043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009984557,"about_ca_system_score_gemma":0.001386251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007617797,"about_ca_topic_score_gemma":0.002625303,"domain_scores_codex":[0.9991327,0.0002877659,0.0001376481,0.0001258702,0.0002314181,0.00008463192],"domain_scores_gemma":[0.9969041,0.002028471,0.0001971761,0.00008532681,0.0005834472,0.000201447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004504026,0.0000892037,0.000772067,0.005792472,0.0001626345,0.000801906,0.0002092549,0.0007591526,0.00214451,0.01844953,0.0608696,0.9094992],"study_design_scores_gemma":[0.0001155637,0.0005982696,0.001320443,0.005169084,0.0002738819,0.003902281,0.0003491102,0.000969213,0.0008756176,0.02455044,0.961805,0.00007091484],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007757882,0.9819008,0.0007667361,0.01379197,0.001106774,0.000007390595,0.00003599521,0.00003253882,0.001582084],"genre_scores_gemma":[0.00889278,0.9729564,0.002004938,0.009559656,0.004768875,0.00003353768,0.00006673912,0.00002812812,0.001688981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004097648,"threshold_uncertainty_score":0.02167076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.032756033502145,"score_gpt":0.3076752592552384,"score_spread":0.2749192257530934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}