{"id":"W4389489603","doi":"10.1038/s41419-023-06241-w","title":"m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Zhongnan Hospital of Wuhan University; Wuhan University; Health Commission of Hubei Province","keywords":"Sting; Immunity; Cell biology; Chemistry; Cancer research; Biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208989,0.0003122197,0.000165062,0.0001862902,0.0001008767,0.0002288008,0.0001203224,0.000187228,0.001003808],"category_scores_gemma":[0.0002581425,0.00007384251,0.000363953,0.0001084703,0.000194797,0.000160415,0.0002242865,0.0002322513,0.0001345788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386513,"about_ca_system_score_gemma":0.0002060844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009346411,"about_ca_topic_score_gemma":0.001013664,"domain_scores_codex":[0.9999034,0.00002949125,0.000005747152,0.0000239199,0.00001761487,0.00001981237],"domain_scores_gemma":[0.9999202,0.00001171359,0.00004061692,0.000008360618,0.000007610237,0.00001139553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007310791,0.00008285898,0.04144289,0.0001314304,0.0001156891,0.0003527256,0.0000758099,0.00884131,0.9197986,0.002791396,0.000260913,0.02537537],"study_design_scores_gemma":[0.00007284358,0.001337981,0.1111245,0.00003042329,0.0002232679,0.0009325027,0.0001428104,0.119113,0.7558444,0.003583841,0.007560173,0.00003428391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876806,0.0007679642,0.01032427,0.00007917713,0.00001192195,0.00001585224,0.0001242161,0.00008205872,0.0009140524],"genre_scores_gemma":[0.9980795,0.0001728803,0.001219639,0.00001172195,0.000002403238,0.000005116473,0.00007780406,0.000002605432,0.0004283866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003808,"threshold_uncertainty_score":0.003358066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178950723288538,"score_gpt":0.2685664573747819,"score_spread":0.2467769501418965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}