{"id":"W4389503873","doi":"10.1016/j.ijrobp.2023.11.055","title":"Randomized Phase 3 Trial of the Hypoxia Modifier Nimorazole Added to Radiation Therapy With Benefit Assessed in Hypoxic Head and Neck Cancers Determined Using a Gene Signature (NIMRAD)","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre","funders":"Manchester Biomedical Research Centre; Cancer Research UK; National Institute for Health and Care Research; Sanofi; Norgine; AstraZeneca","keywords":"Medicine; Radiation therapy; Internal medicine; Placebo; Hypoxia (environmental); Cetuximab; Head and neck squamous-cell carcinoma; Head and neck cancer; Oncology; Clinical endpoint; Adverse effect; Chemoradiotherapy; Randomized controlled trial; Chemotherapy; Gene signature; Cancer; Pathology; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001652168,0.001517404,0.002284427,0.0003199561,0.0004268411,0.001039258,0.0007952618,0.001396971,0.005656399],"category_scores_gemma":[0.001482163,0.0004674388,0.00147329,0.0003603704,0.00115034,0.0007217749,0.00041781,0.002418848,0.0008552456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001172439,"about_ca_system_score_gemma":0.001398253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312433,"about_ca_topic_score_gemma":0.003473089,"domain_scores_codex":[0.9994306,0.0003201485,0.00002082129,0.0001017045,0.00003850227,0.00008816544],"domain_scores_gemma":[0.9991486,0.0002130344,0.000249605,0.00007873416,0.00005395762,0.0002559884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9803625,0.006216242,0.0008441078,0.0002123311,0.0005404297,0.00003037724,0.00004380498,0.0004244256,0.00224231,0.00009294639,0.0007269956,0.008263596],"study_design_scores_gemma":[0.9115874,0.08483236,0.001919929,0.00001584687,0.0002474765,0.00002560395,0.00001985782,0.0003627972,0.0003867648,0.0001297496,0.000462592,0.000009759819],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918312,0.001409995,0.0004454238,0.000480705,0.0003766062,0.00341021,0.0009241669,0.00008274959,0.00103889],"genre_scores_gemma":[0.9866419,0.0008817792,0.001545873,0.001243661,0.000294911,0.005632327,0.001184174,0.00002505101,0.002550392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005656399,"threshold_uncertainty_score":0.01892251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02478617335915055,"score_gpt":0.3371928280748399,"score_spread":0.3124066547156893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}