{"id":"W4389507960","doi":"10.1007/978-1-0716-3593-3_4","title":"Expansion and Retroviral Transduction of Primary Murine T Cells for CAR T-Cell Therapy","year":2023,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Transduction (biophysics); Chimeric antigen receptor; Antigen; Biology; T cell; Transgene; Cell biology; Viral vector; Molecular biology; Immune system; Immunology; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008251228,0.0007662573,0.00055117,0.001045516,0.0005413187,0.0007915847,0.0007349142,0.0007746218,0.007336233],"category_scores_gemma":[0.0004545921,0.0005771811,0.0006470134,0.0005212114,0.0003693723,0.0003920302,0.0005507796,0.003304232,0.003924137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004453891,"about_ca_system_score_gemma":0.0004322294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000746768,"about_ca_topic_score_gemma":0.001044717,"domain_scores_codex":[0.9992197,0.0001312482,0.00008739476,0.0001262058,0.0001856301,0.0002498586],"domain_scores_gemma":[0.9995776,0.0001321669,0.00003609246,0.0001037729,0.00007093934,0.00007948952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001216477,0.0001142789,0.0001022684,0.00004267207,0.000004792068,0.00005808186,0.00007032021,0.0001608461,0.9960835,0.0006077918,0.0003748428,0.002259007],"study_design_scores_gemma":[0.00006246559,0.0003075162,0.0008455834,0.00001672174,0.00002796048,0.0002110285,0.00003101219,0.001294919,0.9798656,0.0001286074,0.01720023,0.000008439869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6870009,0.006112159,0.2482387,0.0008265406,0.001222075,0.008754805,0.0161672,0.002750647,0.02892692],"genre_scores_gemma":[0.8388038,0.004381593,0.1012195,0.0006032861,0.0003286425,0.005766038,0.01256798,0.0009104627,0.03541866],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.007336233,"threshold_uncertainty_score":0.02454215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04990881097312872,"score_gpt":0.4178000813241969,"score_spread":0.3678912703510682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}