{"id":"W4389508010","doi":"10.1007/978-1-0716-3593-3_17","title":"Nano-optogenetic CAR-T Cell Immunotherapy","year":2023,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chimeric antigen receptor; Optogenetics; Immunotherapy; Cancer immunotherapy; Cytokine release syndrome; Cell; Cancer research; Medicine; Immunology; Chemistry; Biology; Immune system; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527919,0.0002808438,0.0001655075,0.0001855163,0.000137706,0.0004301589,0.0003007187,0.0004459932,0.00373009],"category_scores_gemma":[0.0001074666,0.0001398973,0.0002384801,0.0001331685,0.0002636045,0.0003981026,0.0003184337,0.0005088421,0.0007347293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462945,"about_ca_system_score_gemma":0.0002522461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000339203,"about_ca_topic_score_gemma":0.0006502892,"domain_scores_codex":[0.9998825,0.00001217431,0.000004486266,0.00002850893,0.0000460046,0.00002624533],"domain_scores_gemma":[0.9999651,0.00001214702,0.000008159464,0.000005424841,0.000004118807,0.0000050589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000732663,0.0000446746,0.0001306185,0.00009802449,0.000009954228,0.0000487547,0.00002103874,0.0008473954,0.9759134,0.006844812,0.001082418,0.01488551],"study_design_scores_gemma":[0.00003225332,0.0001457979,0.0005893615,0.00001054636,0.00002139681,0.0002265997,0.00002687495,0.007181081,0.9601134,0.001818626,0.02982218,0.00001180293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6139114,0.01469281,0.2738971,0.003531197,0.001877549,0.0004992616,0.001421953,0.001727965,0.08844079],"genre_scores_gemma":[0.9204846,0.00265254,0.05058143,0.0008497511,0.0001593602,0.0002736317,0.0002762983,0.0001276687,0.02459485],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00373009,"threshold_uncertainty_score":0.01247841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04397838864026288,"score_gpt":0.4487238117596422,"score_spread":0.4047454231193793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}