{"id":"W4389514328","doi":"10.1093/ecco-jcc/jjad206","title":"Risankizumab Induction Therapy Achieves Early Symptom Improvements That Are Associated With Future Clinical and Endoscopic Outcomes in Crohn’s Disease: Post Hoc Analysis of the ADVANCE, MOTIVATE, and FORTIFY Phase 3 Studies","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Crohn's disease; Post-hoc analysis; Medicine; Post hoc; Disease; Physical therapy; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0174687,0.001118169,0.003019123,0.0004518218,0.0002667972,0.001191965,0.0007169324,0.000830703,0.001956708],"category_scores_gemma":[0.008523222,0.0004390083,0.005834244,0.0003589073,0.0007888276,0.000868597,0.0007376008,0.001686756,0.0002719409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003782854,"about_ca_system_score_gemma":0.0008061266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558173,"about_ca_topic_score_gemma":0.0004839309,"domain_scores_codex":[0.9931306,0.005101677,0.0003126411,0.0005164506,0.0004656867,0.0004728918],"domain_scores_gemma":[0.9847026,0.01022765,0.002110708,0.001648135,0.0005308382,0.0007799892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9115342,0.002830513,0.04734931,0.0005134972,0.0127939,0.0001334591,0.0001549661,0.002223099,0.005396737,0.0001186386,0.0007080279,0.01624358],"study_design_scores_gemma":[0.09233037,0.4877021,0.3624065,0.0001025295,0.03120443,0.0003828714,0.0002531578,0.01211798,0.009652902,0.0004323428,0.003286449,0.0001283652],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972827,0.001023945,0.0004937184,0.00006490258,0.00003850033,0.0002575323,0.0003811998,0.00002175262,0.000435753],"genre_scores_gemma":[0.9973956,0.0002072118,0.0006753454,0.00007320737,0.00005646059,0.0003379617,0.0006494328,0.0000161696,0.0005885845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0174687,"threshold_uncertainty_score":0.09238446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751312344134838,"score_gpt":0.3156332752493184,"score_spread":0.29812015180797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}