{"id":"W4389515272","doi":"10.1101/2023.12.04.569954","title":"SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; University of Toronto; International Development Research Centre; Canada First Research Excellence Fund; Government of Ontario; Princess Margaret Cancer Foundation; St. Jude Children's Research Hospital; American Lebanese Syrian Associated Charities; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Lymphoblastic Leukemia; Dissection (medical); Leukemia; Biology; Cell; Cancer research; Medicine; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004962584,0.0005996753,0.0008756185,0.0007495634,0.00009522308,0.00007450773,0.0003125107,0.0006734735,0.00003260236],"category_scores_gemma":[0.0001245078,0.0006367136,0.0001748655,0.0007819112,0.0002620632,0.0001359105,0.0004064872,0.0007745153,0.00005805317],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006393026,"about_ca_system_score_gemma":0.004277352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003183266,"about_ca_topic_score_gemma":0.0000322594,"domain_scores_codex":[0.9963638,0.0001155738,0.0008588787,0.001141248,0.0008154503,0.0007050697],"domain_scores_gemma":[0.9982033,0.0001522077,0.0002953498,0.0005901948,0.0003450338,0.0004138625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003385363,0.0004486762,0.02151238,0.001487853,0.0001930051,0.0003059707,0.00004153189,0.00008272175,0.9754366,0.00004839435,0.0001022273,0.000002079219],"study_design_scores_gemma":[0.004267258,0.0002284374,0.2197201,0.0007547821,0.0002686954,8.342985e-7,0.00001313209,0.001772995,0.7720266,0.000001623401,0.0003883158,0.0005572627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958517,0.0003755889,0.001279714,0.0000676012,0.0005928455,0.001171298,0.0004210114,0.0002177279,0.00002251746],"genre_scores_gemma":[0.993833,0.000397316,0.005097714,0.00005610688,0.0001858865,0.0002139321,0.000004970309,0.0001782178,0.00003287333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2034101,"threshold_uncertainty_score":0.9996084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285602193624356,"score_gpt":0.24715104132179,"score_spread":0.2242950193855464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}