{"id":"W4389515272","doi":"10.1101/2023.12.04.569954","title":"SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; University of Toronto; International Development Research Centre; Canada First Research Excellence Fund; Government of Ontario; Princess Margaret Cancer Foundation; St. Jude Children's Research Hospital; American Lebanese Syrian Associated Charities; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Lymphoblastic Leukemia; Dissection (medical); Leukemia; Biology; Cell; Cancer research; Medicine; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003064428,0.0001256663,0.0002194351,0.0004403906,0.0001362604,0.0003873921,0.000106912,0.0001486181,0.000764876],"category_scores_gemma":[0.0002938652,0.0001522673,0.0001384173,0.0003572094,0.0001765821,0.0001169594,0.0002226404,0.0002011071,0.0003642777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870982,"about_ca_system_score_gemma":0.000125809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007716973,"about_ca_topic_score_gemma":0.001516413,"domain_scores_codex":[0.9998536,0.00001981785,0.000007680892,0.00005137531,0.00004512937,0.00002238999],"domain_scores_gemma":[0.9998653,0.00005142051,0.00002306367,0.00002307259,0.00002255719,0.00001472036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001425854,0.000009466211,0.01518238,0.00004531998,0.0000183554,0.0000307706,0.00005286515,0.0005406518,0.9776661,0.0001279794,0.0001577922,0.006025788],"study_design_scores_gemma":[0.00002444212,0.0001305421,0.3443382,0.00001629484,0.00006677704,0.0005755314,0.0002157288,0.01355161,0.6314232,0.001294076,0.008347474,0.00001615565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815137,0.0008776978,0.01328609,0.00006470083,0.00001052767,0.00001997392,0.003094356,0.0001623101,0.0009706579],"genre_scores_gemma":[0.9856058,0.0004300151,0.008266624,0.00007143943,0.000009594866,0.00003863635,0.004575412,0.00008437635,0.0009180759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007716973,"threshold_uncertainty_score":0.002558768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285602193624356,"score_gpt":0.24715104132179,"score_spread":0.2242950193855464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}