{"id":"W4389515731","doi":"10.1101/2023.12.07.569977","title":"Functional genetic characterization of stress tolerance and biofilm formation in <i>Nakaseomyces glabrata</i> via a novel CRISPR activation system","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; CRISPR; Gene; Phenotype; Candida glabrata; Gene duplication; Genetics; RNA interference; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898973,0.0004126461,0.0003139413,0.0003004734,0.0001858327,0.0004138953,0.000280516,0.0003179756,0.001064174],"category_scores_gemma":[0.0002202016,0.0001309862,0.0003262699,0.0001942986,0.0002239032,0.0001233428,0.0003925352,0.000557534,0.0007170072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997455,"about_ca_system_score_gemma":0.0001909145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001871657,"about_ca_topic_score_gemma":0.001573033,"domain_scores_codex":[0.9997402,0.00003705651,0.00004151186,0.00005640107,0.00009508567,0.00002981775],"domain_scores_gemma":[0.999744,0.00005037595,0.00008546435,0.00004847889,0.00002879435,0.00004285001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000100728,0.00000580729,0.00007346051,0.000006128452,0.00000107907,0.0000191397,0.000006735939,0.00002462736,0.9994996,0.00002139444,0.00001189463,0.000320024],"study_design_scores_gemma":[0.000006057491,0.00006248468,0.004843754,0.00000354987,0.000005858649,0.0001928357,0.0000244132,0.0008470952,0.9917418,0.00002955181,0.002234241,0.000008408821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726532,0.0003834635,0.02166951,0.000181072,0.00003770214,0.00009151967,0.002362992,0.0005628561,0.002057813],"genre_scores_gemma":[0.9752373,0.0002600017,0.01666541,0.00006980375,0.000007442382,0.00006404049,0.002937769,0.0002382326,0.004519973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871657,"threshold_uncertainty_score":0.003721476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964115995550302,"score_gpt":0.2239696696667532,"score_spread":0.2043285097112502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}