{"id":"W4389547308","doi":"10.1155/2023/5279979","title":"A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern","year":2023,"lang":"en","type":"article","venue":"Transboundary and Emerging Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Ministry of Education – Kingdom of Saudi Arabi; King Abdulaziz University","keywords":"Immunogenicity; Furin; Immune system; Virology; Biology; Neutralization; DNA vaccination; Antibody; Recombinant DNA; Humoral immunity; Immunity; Neutralizing antibody; Proteases; Immunology; Virus; Gene; Genetics; Immunization; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006496817,0.0005274713,0.001033803,0.0004672837,0.0006844922,0.000165097,0.000278054,0.0001815083,0.00001016679],"category_scores_gemma":[0.0001949833,0.00048641,0.0002436147,0.0008818281,0.0004779331,0.0003414871,0.000120903,0.0004604341,0.000009612409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000854868,"about_ca_system_score_gemma":0.0007397714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435561,"about_ca_topic_score_gemma":0.00009385625,"domain_scores_codex":[0.9965204,0.0003313611,0.0007819152,0.0007917504,0.0006765592,0.0008980418],"domain_scores_gemma":[0.9985779,0.0002061878,0.000179711,0.0006991517,0.0002111594,0.0001259165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004170941,0.000740557,0.006294638,0.002126239,0.0001914965,0.0003914773,0.001255078,0.00001330044,0.9788092,0.00007099917,0.0001661898,0.005769826],"study_design_scores_gemma":[0.01235631,0.0008338553,0.008317177,0.001414569,0.0003958796,0.00001361407,0.0004589027,0.01120763,0.9588545,0.001028095,0.004457273,0.0006621921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941971,0.002572374,0.0004631291,0.0004274262,0.0001543223,0.001419597,0.0001389438,0.0003385149,0.0002885604],"genre_scores_gemma":[0.9968625,0.00006900571,0.0001613744,0.002476366,0.0000708728,0.0001351958,0.0001031659,0.00009710293,0.0000243778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01995477,"threshold_uncertainty_score":0.9997588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05851273179170562,"score_gpt":0.330975191526467,"score_spread":0.2724624597347614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}