{"id":"W4389547308","doi":"10.1155/2023/5279979","title":"A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern","year":2023,"lang":"en","type":"article","venue":"Transboundary and Emerging Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Ministry of Education – Kingdom of Saudi Arabi; King Abdulaziz University","keywords":"Immunogenicity; Furin; Immune system; Virology; Biology; Neutralization; DNA vaccination; Antibody; Recombinant DNA; Humoral immunity; Immunity; Neutralizing antibody; Proteases; Immunology; Virus; Gene; Genetics; Immunization; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009090471,0.0004052153,0.0002656276,0.0001365171,0.00007041632,0.0001338936,0.000171961,0.0003584743,0.0005476862],"category_scores_gemma":[0.00009488359,0.0001163728,0.0002207252,0.00009877892,0.0001625843,0.0001510615,0.0001230727,0.0005374608,0.000195311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788423,"about_ca_system_score_gemma":0.0001567511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002089116,"about_ca_topic_score_gemma":0.0003522303,"domain_scores_codex":[0.9998924,0.00001611299,0.000008406163,0.00002455455,0.00003070574,0.00002779029],"domain_scores_gemma":[0.999952,0.000006845333,0.00001710771,0.000005729973,0.000007431949,0.00001086846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008210062,0.00006801171,0.0001504064,0.00002111549,0.000003636589,0.00001992077,0.000007020379,0.0001402905,0.9984793,0.00003442204,0.00001623389,0.000977445],"study_design_scores_gemma":[0.00006508063,0.003766095,0.003399391,0.000007834543,0.0000257636,0.000314582,0.00002127826,0.002170912,0.9886339,0.00004399991,0.001544133,0.000007008039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980223,0.0001798516,0.001263756,0.0000274286,0.00001591841,0.00002574402,0.00006669675,0.00002920249,0.0003690385],"genre_scores_gemma":[0.9961303,0.0001773524,0.002136278,0.00004964714,0.000009294092,0.00002821445,0.0004665067,0.000006973331,0.0009953453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005476862,"threshold_uncertainty_score":0.001832187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05851273179170562,"score_gpt":0.330975191526467,"score_spread":0.2724624597347614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}