{"id":"W4389549604","doi":"10.1038/s41586-023-06903-x","title":"Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC","funders":"Stanford Cancer Institute; National Heart, Lung, and Blood Institute; Regeneron Pharmaceuticals; National Institutes of Health; Pharmacyclics; Genentech; Deutsche Krebshilfe; Chugai Pharmaceutical; Seagen; Pfizer; Incyte; Emerson Collective; BeiGene; Varian Medical Systems; Celgene; Bristol-Myers Squibb; AstraZeneca; TG Therapeutics; Canadian Institutes of Health Research; Adaptive Biotechnologies; Damon Runyon Cancer Research Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Kite Pharma; National Cancer Institute; Gilead Sciences; U.S. Department of Defense","keywords":"Hodgkin lymphoma; Lymphoma; Computational biology; Profiling (computer programming); Biology; Cancer research; Medicine; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004058632,0.0002467852,0.0003257161,0.0008686574,0.0002564606,0.001097384,0.0003282806,0.0004244561,0.001628845],"category_scores_gemma":[0.001148038,0.0001477293,0.0001656969,0.0005160093,0.0004398742,0.0005520189,0.0006324774,0.0004264919,0.0003793837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328929,"about_ca_system_score_gemma":0.0002141545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005139378,"about_ca_topic_score_gemma":0.001366912,"domain_scores_codex":[0.9996212,0.00006426228,0.00002475963,0.00007628337,0.00009832583,0.0001151536],"domain_scores_gemma":[0.9996312,0.0001064301,0.00009840064,0.00004922902,0.00005443905,0.00006024014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001623174,0.0001561856,0.783189,0.00009707554,0.00008395036,0.002459571,0.0006025544,0.0005001595,0.1154346,0.002507881,0.001730507,0.09161544],"study_design_scores_gemma":[0.0001229176,0.0004283482,0.9412032,0.00009689025,0.0001747612,0.01739719,0.001983687,0.003366161,0.01786961,0.006991999,0.01033786,0.00002732881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988467,0.001510611,0.002499233,0.0003850755,0.00002784049,0.00005737001,0.0003702993,0.00004944769,0.006633272],"genre_scores_gemma":[0.9969591,0.0004221342,0.001411489,0.000179111,0.00003411778,0.00002703875,0.0004476279,0.00001561433,0.000503805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628845,"threshold_uncertainty_score":0.005449057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002489229160942,"score_gpt":0.2615826605127972,"score_spread":0.2515577682211877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}