{"id":"W4389549604","doi":"10.1038/s41586-023-06903-x","title":"Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC","funders":"Stanford Cancer Institute; National Heart, Lung, and Blood Institute; Regeneron Pharmaceuticals; National Institutes of Health; Pharmacyclics; Genentech; Deutsche Krebshilfe; Chugai Pharmaceutical; Seagen; Pfizer; Incyte; Emerson Collective; BeiGene; Varian Medical Systems; Celgene; Bristol-Myers Squibb; AstraZeneca; TG Therapeutics; Canadian Institutes of Health Research; Adaptive Biotechnologies; Damon Runyon Cancer Research Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Kite Pharma; National Cancer Institute; Gilead Sciences; U.S. Department of Defense","keywords":"Hodgkin lymphoma; Lymphoma; Computational biology; Profiling (computer programming); Biology; Cancer research; Medicine; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008741052,0.0001829781,0.0002596188,0.00008587808,0.00009612575,0.00002468404,0.00008418801,0.0005787914,0.00006711916],"category_scores_gemma":[0.0001510006,0.0001366002,0.0001180694,0.0003301431,0.00003094601,0.0000336584,0.00005192133,0.0002808455,0.0005867794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303774,"about_ca_system_score_gemma":0.0001483384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003637587,"about_ca_topic_score_gemma":0.00001462805,"domain_scores_codex":[0.9989516,0.00002050872,0.0001521386,0.0003327976,0.0002393315,0.0003036259],"domain_scores_gemma":[0.9993497,0.0001428009,0.0000561511,0.0002637228,0.00006420226,0.0001233967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003416997,0.0009528243,0.696826,0.0002101747,0.0005425376,0.001988933,0.0003149711,0.00000334926,0.02513896,0.002133658,0.2372371,0.03430979],"study_design_scores_gemma":[0.004749327,0.0002897328,0.8627456,0.0001130971,0.000232271,0.0001509668,0.0001038442,0.0001079933,0.08023632,0.00024061,0.05076467,0.0002655739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898535,0.003310944,0.000001615876,0.002377611,0.0003007729,0.0003700392,0.000106234,0.0002325933,0.003446695],"genre_scores_gemma":[0.9955873,0.0001811187,0.0004310007,0.0008947972,0.0001973412,0.00007774215,0.0007192991,0.00003416361,0.001877206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1864724,"threshold_uncertainty_score":0.7542058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002489229160942,"score_gpt":0.2615826605127972,"score_spread":0.2515577682211877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}