{"id":"W4389558793","doi":"10.1128/msphere.00379-23","title":"Microbiota-mediated effects of Parkinson’s disease medications on Parkinsonian non-motor symptoms in male transgenic mice","year":2023,"lang":"en","type":"article","venue":"mSphere","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Gut flora; Parkinson's disease; Medicine; Constipation; Carbidopa; Internal medicine; Dopaminergic; Disease; Gastroenterology; Dopamine; Levodopa; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004188895,0.0009612893,0.0008359904,0.001334513,0.0005267487,0.0006730029,0.0005685681,0.001358979,0.003313783],"category_scores_gemma":[0.0002485868,0.0006650894,0.00112114,0.0003884966,0.0008397875,0.0005095626,0.0005306021,0.002549872,0.0006291152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007151166,"about_ca_system_score_gemma":0.0005553764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001863341,"about_ca_topic_score_gemma":0.00390658,"domain_scores_codex":[0.9991491,0.000105257,0.0001061857,0.0002861814,0.0002032795,0.0001499355],"domain_scores_gemma":[0.999158,0.00007569608,0.0003111128,0.00005306467,0.00007771482,0.0003244581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001052001,0.0004434374,0.0005186907,0.00007424363,0.0000231874,0.0001872068,0.0000624778,0.00006718749,0.9959667,0.0001124598,0.0001134972,0.001378846],"study_design_scores_gemma":[0.0005439041,0.007303805,0.02565359,0.00007907756,0.0002307885,0.001120527,0.0003727541,0.002349983,0.9556186,0.0002703118,0.006395321,0.00006143989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888049,0.001356333,0.003342269,0.0005417402,0.0001838187,0.0001853042,0.003734353,0.0003353132,0.001516002],"genre_scores_gemma":[0.9710807,0.002046077,0.008047432,0.000574364,0.00006518712,0.0007287308,0.003295546,0.0002695157,0.01389251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003313783,"threshold_uncertainty_score":0.01108569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006904660220260738,"score_gpt":0.2424522337307147,"score_spread":0.2355475735104539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}