{"id":"W4389565816","doi":"10.15252/embj.2023113590","title":"Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Institut Curie; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Wellcome Trust; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Fondation pour la Recherche Médicale; Centre National de la Recherche Scientifique; National Cancer Institute; CNIB; Francis Crick Institute; Infrastructures en Biologie Santé et Agronomie","keywords":"Biology; Cell biology; Extracellular; Microvesicles; Dendritic cell; Antigen presentation; Immune system; Extracellular vesicle; Intracellular; Priming (agriculture); Extracellular vesicles; Secretion; Cell culture; Antigen-presenting cell; Endogeny; Immunology; T cell; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717351,0.0003540816,0.0002933233,0.000258384,0.000142274,0.0005122538,0.0001970121,0.0003834915,0.000655339],"category_scores_gemma":[0.0002436695,0.0001473071,0.0003338369,0.0002299584,0.0002493148,0.000293103,0.0003313753,0.0007235476,0.0004425706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002680846,"about_ca_system_score_gemma":0.0001790814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036518,"about_ca_topic_score_gemma":0.0003551871,"domain_scores_codex":[0.9995283,0.0001102185,0.00005989375,0.00009986934,0.00008966464,0.0001119259],"domain_scores_gemma":[0.9997779,0.00008953867,0.00003092556,0.00004343389,0.00002795507,0.00003029128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118615,0.00003102142,0.0001599447,0.00002687911,0.000006494306,0.00003555647,0.00001924711,0.00005774126,0.9987936,0.0001562147,0.00001860373,0.0005828289],"study_design_scores_gemma":[0.000009611597,0.0001348201,0.0006956303,0.000002467996,0.00001162446,0.0001088852,0.00001399605,0.0003698739,0.9974567,0.00003340666,0.00116062,0.00000230675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881867,0.001499294,0.007481543,0.00008907077,0.0001080743,0.00009083965,0.0006777436,0.00006904952,0.001797796],"genre_scores_gemma":[0.9895075,0.0007850385,0.00571363,0.00007008779,0.00002519964,0.0001198612,0.001212279,0.0000851842,0.002481106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000655339,"threshold_uncertainty_score":0.002192378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210178561633102,"score_gpt":0.2624111807575317,"score_spread":0.2413933245942215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}