{"id":"W4389565816","doi":"10.15252/embj.2023113590","title":"Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Institut Curie; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Wellcome Trust; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Fondation pour la Recherche Médicale; Centre National de la Recherche Scientifique; National Cancer Institute; CNIB; Francis Crick Institute; Infrastructures en Biologie Santé et Agronomie","keywords":"Biology; Cell biology; Extracellular; Microvesicles; Dendritic cell; Antigen presentation; Immune system; Extracellular vesicle; Intracellular; Priming (agriculture); Extracellular vesicles; Secretion; Cell culture; Antigen-presenting cell; Endogeny; Immunology; T cell; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714402,0.000280987,0.0002414541,0.00007114839,0.0003900084,0.000172202,0.0004745235,0.000129974,0.0002316805],"category_scores_gemma":[0.00004873695,0.0002166555,0.0001680849,0.0001355712,0.0002006437,0.00001113537,0.0001932359,0.0003522571,0.00008103906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002730729,"about_ca_system_score_gemma":0.0001053783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005601267,"about_ca_topic_score_gemma":0.00002973848,"domain_scores_codex":[0.9981698,0.0003205629,0.0003497136,0.0003701386,0.0002901042,0.0004997303],"domain_scores_gemma":[0.9989326,0.00009545016,0.0001880095,0.000458539,0.00006867126,0.0002567505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685467,0.00006964208,0.00120693,0.0000215686,0.0002079965,0.0003109793,0.0001585011,0.0001482109,0.9932379,0.00001169449,0.002893304,0.001564734],"study_design_scores_gemma":[0.0009019796,0.0001853071,0.003112502,0.0000501293,0.0001849669,0.0001533652,0.0001335946,0.0003083445,0.9916794,0.0004847608,0.002505294,0.000300348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807814,0.01737022,0.0006384402,0.0001372185,0.0005888251,0.0002161755,0.0001454258,0.00004395521,0.00007830973],"genre_scores_gemma":[0.9937642,0.004079379,0.000159461,0.0001185157,0.0009172474,0.00001394723,0.00005969215,0.00007045204,0.0008171293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01329084,"threshold_uncertainty_score":0.8834956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210178561633102,"score_gpt":0.2624111807575317,"score_spread":0.2413933245942215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}