{"id":"W4389568253","doi":"10.1016/j.omtm.2023.101171","title":"Manufacture of CD22 CAR T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"NIH Clinical Center; U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; Australian Government; Center for Cancer Research","keywords":"Cart; CD8; Leukapheresis; Chimeric antigen receptor; Peripheral blood mononuclear cell; Biology; Cytotoxic T cell; T cell; Cytokine; Immunology; Antigen; Cancer research; Cell biology; Immune system; Stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037666,0.0004154932,0.0002488246,0.0001865003,0.000136665,0.0006748224,0.0001576203,0.0002851569,0.002057066],"category_scores_gemma":[0.0002678455,0.0001252225,0.0001745953,0.0001630693,0.0001960865,0.0001677261,0.0001696283,0.0005739973,0.0009390858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184173,"about_ca_system_score_gemma":0.000160317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001425161,"about_ca_topic_score_gemma":0.0002343294,"domain_scores_codex":[0.9995099,0.0001035217,0.00005943864,0.0001060213,0.0001469008,0.00007418246],"domain_scores_gemma":[0.9998397,0.00003988436,0.00002895788,0.00003197154,0.00003215927,0.00002729163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002023106,0.00007192813,0.0002628105,0.00003799086,0.000005841482,0.00004003705,0.00004006077,0.00009811983,0.9952378,0.0001436712,0.000124434,0.003734969],"study_design_scores_gemma":[0.00002019407,0.0004348423,0.0009067158,0.000004285705,0.00001679995,0.0001963664,0.00001446228,0.0005692394,0.9948426,0.00003665888,0.002953948,0.000004011464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737856,0.0009471673,0.01925768,0.0001292603,0.00007473097,0.0003349637,0.0004977408,0.0002419317,0.004730932],"genre_scores_gemma":[0.977973,0.0005506885,0.01516723,0.0001485061,0.00002617918,0.0003133891,0.001075501,0.00009487357,0.00465053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002057066,"threshold_uncertainty_score":0.006881595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07940232075959335,"score_gpt":0.4330534113470235,"score_spread":0.3536510905874301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}