{"id":"W4389607710","doi":"10.1002/advs.202305035","title":"Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple‐Negative Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Hunan Provincial Innovation Foundation for Postgraduate; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Triple-negative breast cancer; Paclitaxel; Cancer research; Ubiquitin ligase; In vivo; Breast cancer; In vitro; Targeted therapy; Drug; Medicine; Protein degradation; Cancer; Ubiquitin; Pharmacology; Chemistry; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655571,0.0003851154,0.0004255762,0.0002788207,0.0001365787,0.0003009487,0.0002538914,0.0003294761,0.0006362434],"category_scores_gemma":[0.0001106815,0.0001238368,0.0003130361,0.0001716625,0.0001140139,0.0001487517,0.0001250355,0.000322474,0.0003290203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003160832,"about_ca_system_score_gemma":0.0003132525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004610245,"about_ca_topic_score_gemma":0.0006792636,"domain_scores_codex":[0.9999173,0.00001016009,0.000008729332,0.00001715669,0.00002524698,0.0000214011],"domain_scores_gemma":[0.9999347,0.000004206694,0.00002000254,0.000004926034,0.00001219835,0.00002396572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001955238,0.0001700484,0.0001234617,0.0001361138,0.00001982828,0.0001743665,0.00001759177,0.0007755602,0.990417,0.0001496686,0.0001347634,0.007686132],"study_design_scores_gemma":[0.0002730833,0.00350829,0.001533873,0.00001549019,0.00007296182,0.0007751629,0.00001888546,0.002303197,0.9790366,0.00004377328,0.01239357,0.00002507422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709376,0.007814066,0.0154299,0.0003291864,0.00007110212,0.000571843,0.000808529,0.0001440871,0.003893821],"genre_scores_gemma":[0.9811327,0.003864139,0.01043969,0.0001445985,0.00002714464,0.0002041354,0.000974151,0.00002075524,0.003192722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006362434,"threshold_uncertainty_score":0.002293348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03179178261054299,"score_gpt":0.3034776683179363,"score_spread":0.2716858857073933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}