{"id":"W4389609538","doi":"10.1016/j.isci.2023.108681","title":"HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"HORIZON EUROPE Framework Programme; China Scholarship Council; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; H2020 European Research Council; Velux Stiftung","keywords":"HDAC1; Transcriptome; Phenotype; Bioinformatics; Dementia; Histone deacetylase; Histone deacetylase inhibitor; Disease; Medicine; Contractility; Epigenetics; Longevity; Fibrosis; HDAC3; Translation (biology); Biology; Histone; Neuroscience; Gene expression; Gene; Internal medicine; Genetics; Gerontology; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005953427,0.0001199323,0.0001141524,0.0001455028,0.0001213848,0.00005877995,0.0003818512,0.0001054338,0.000005014751],"category_scores_gemma":[0.0003261285,0.0001080421,0.00004034626,0.0007680348,0.0001934052,0.000009400212,0.0001564481,0.0001284114,0.0001393252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003769639,"about_ca_system_score_gemma":0.0001485203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002939518,"about_ca_topic_score_gemma":0.0002198091,"domain_scores_codex":[0.998518,0.00009372509,0.0001910155,0.0004660319,0.0002996286,0.000431605],"domain_scores_gemma":[0.9994178,0.00003654147,0.00004233599,0.0003461922,0.0000607667,0.00009629541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002485167,0.00003230077,0.001414516,0.00000966399,0.000002547203,0.00001484296,0.0001999035,0.00008092752,0.9917392,0.000003794122,0.004448574,0.00202888],"study_design_scores_gemma":[0.0006266577,0.0001553496,0.007896035,0.00002075077,5.279317e-7,0.000008380649,0.00029894,0.001065727,0.9661463,0.000003980455,0.0236005,0.0001768568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977124,0.001045809,0.00003142192,0.0001410299,0.0003975954,0.0002956006,0.00001204903,0.00003878901,0.000325352],"genre_scores_gemma":[0.9971214,0.0001772767,0.00005184924,0.00006045369,0.000212888,0.00005653913,0.00002594669,0.00001944628,0.002274219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0255929,"threshold_uncertainty_score":0.4405828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908390199595581,"score_gpt":0.2873316080898687,"score_spread":0.2682477060939129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}