{"id":"W4389609538","doi":"10.1016/j.isci.2023.108681","title":"HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"HORIZON EUROPE Framework Programme; China Scholarship Council; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; H2020 European Research Council; Velux Stiftung","keywords":"HDAC1; Transcriptome; Phenotype; Bioinformatics; Dementia; Histone deacetylase; Histone deacetylase inhibitor; Disease; Medicine; Contractility; Epigenetics; Longevity; Fibrosis; HDAC3; Translation (biology); Biology; Histone; Neuroscience; Gene expression; Gene; Internal medicine; Genetics; Gerontology; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458439,0.000669764,0.0005108297,0.000533342,0.0001548004,0.0002831821,0.0002417691,0.0003029119,0.001692357],"category_scores_gemma":[0.00008136982,0.0001662749,0.0004363026,0.0001491145,0.0002218896,0.0002880468,0.0001597837,0.0008277826,0.0003431161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427938,"about_ca_system_score_gemma":0.0002386345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004872065,"about_ca_topic_score_gemma":0.001596002,"domain_scores_codex":[0.9998778,0.00001144726,0.00001301346,0.00003907862,0.0000259846,0.00003269491],"domain_scores_gemma":[0.9998937,0.000005742537,0.00003501785,0.00001020445,0.00001203659,0.0000433071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004546223,0.0001535691,0.0002478681,0.00004898831,0.00001832642,0.00003015715,0.000009096214,0.0001053933,0.9938199,0.00008066131,0.0001345654,0.004896886],"study_design_scores_gemma":[0.000091151,0.003328525,0.006603168,0.00001663511,0.00008146611,0.0001394965,0.00002752143,0.0006980374,0.9853849,0.000111818,0.003508316,0.000008849031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831567,0.005025724,0.005953858,0.0002790195,0.0001788291,0.00006641493,0.00217181,0.0004978992,0.002669637],"genre_scores_gemma":[0.9796501,0.004333666,0.005418783,0.0003964364,0.00004788002,0.00009383523,0.002099958,0.00009873711,0.007860587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692357,"threshold_uncertainty_score":0.005661488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908390199595581,"score_gpt":0.2873316080898687,"score_spread":0.2682477060939129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}