{"id":"W4389615151","doi":"10.1084/jem.20230063","title":"Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Center for Comparative Immigration Studies, University of California, San Diego; Chiba University; University of California, San Diego; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Hartwell Foundation; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development; National Academies of Sciences, Engineering, and Medicine; Canadian Institute for Advanced Research; Ford Foundation","keywords":"Biology; Immune system; Bacteroides fragilis; FOXP3; Immunology; Signal transduction; Immune tolerance; Interferon; Microbiology; Cell biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001368181,0.0001126028,0.0002798486,0.0002041063,0.00007198855,0.00000458234,0.0002578326,0.0000600062,0.000402301],"category_scores_gemma":[0.0001134855,0.00006998848,0.00003361271,0.000290417,0.00009384639,0.00008346688,0.00007421336,0.0002718688,0.0002127512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008443637,"about_ca_system_score_gemma":0.00002725917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000059253,"about_ca_topic_score_gemma":0.000001688483,"domain_scores_codex":[0.9987799,0.00033565,0.0005438844,0.00006836788,0.00005711667,0.0002151045],"domain_scores_gemma":[0.9994452,0.000161606,0.0001921519,0.000123172,0.00005825161,0.00001964024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003456351,0.00003855017,0.00002806319,0.000004408163,0.00004002409,0.00001607927,0.008392038,0.0000263251,0.9852559,0.00004085496,0.001932944,0.0007684645],"study_design_scores_gemma":[0.001708494,0.002261854,0.00142635,0.0004305536,0.00001459945,0.0001485951,0.006824483,0.00001460857,0.983014,0.00003048534,0.004049989,0.00007598138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908801,0.004097604,0.00003721688,0.003508468,0.001182203,0.0001751748,5.109344e-7,0.00001335647,0.0001053337],"genre_scores_gemma":[0.9991174,0.00008886194,0.0000354836,0.0003179646,0.0001023307,0.00000300428,0.000009644977,0.00001161215,0.0003136692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008237297,"threshold_uncertainty_score":0.4404914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948895189050471,"score_gpt":0.2968835369182332,"score_spread":0.2773945850277285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}