{"id":"W4389615151","doi":"10.1084/jem.20230063","title":"Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Center for Comparative Immigration Studies, University of California, San Diego; Chiba University; University of California, San Diego; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Hartwell Foundation; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development; National Academies of Sciences, Engineering, and Medicine; Canadian Institute for Advanced Research; Ford Foundation","keywords":"Biology; Immune system; Bacteroides fragilis; FOXP3; Immunology; Signal transduction; Immune tolerance; Interferon; Microbiology; Cell biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408167,0.0007000363,0.0003600696,0.0009406274,0.0003166497,0.0005348359,0.0003605361,0.0006495955,0.001856882],"category_scores_gemma":[0.0001883462,0.0004004375,0.0004242452,0.0002526861,0.00065876,0.0004228222,0.0003792983,0.002109855,0.0006460817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621454,"about_ca_system_score_gemma":0.0004472029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004326094,"about_ca_topic_score_gemma":0.0008774528,"domain_scores_codex":[0.9995626,0.00007463664,0.00003840672,0.00008466857,0.00008775905,0.0001521114],"domain_scores_gemma":[0.9995474,0.00003396723,0.0001557764,0.00005732597,0.00002279587,0.0001827811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006810182,0.0002541888,0.0003325925,0.00003550967,0.000007401658,0.00006850643,0.00003203335,0.0000853507,0.9961965,0.000296468,0.00009413816,0.001916342],"study_design_scores_gemma":[0.0002175146,0.002256165,0.01075079,0.00005864132,0.00003881977,0.0006036431,0.0001158386,0.002709058,0.9784565,0.0005684292,0.004205711,0.00001876473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912993,0.001346249,0.003241841,0.0004199451,0.00007244397,0.00006759428,0.0006798106,0.0003748906,0.002497963],"genre_scores_gemma":[0.9896228,0.0007659594,0.003963483,0.0003090031,0.00003781768,0.0001170158,0.0004406154,0.0001032884,0.004639969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856882,"threshold_uncertainty_score":0.006211936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948895189050471,"score_gpt":0.2968835369182332,"score_spread":0.2773945850277285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}