{"id":"W4389615197","doi":"10.1016/j.immuni.2023.11.011","title":"Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; NYU Grossman School of Medicine; Swiss Cancer Research Foundation; National Cancer Institute; National Institutes of Health; National Science Foundation; Cincinnati Children's Hospital Medical Center; York University; Leukemia and Lymphoma Society; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Astrogliosis; Myeloid; Biology; Microglia; Neuroinflammation; Inflammation; Neurodegeneration; Pathology; Cancer research; Immunology; Medicine; Neuroscience; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491412,0.0002343205,0.0002127092,0.0003706166,0.0001576933,0.000229068,0.0001260433,0.000280738,0.001364513],"category_scores_gemma":[0.0001891917,0.0001113738,0.000104155,0.0001815022,0.0003266967,0.0002064998,0.0002616255,0.0003585446,0.0002410155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962459,"about_ca_system_score_gemma":0.0001269378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407863,"about_ca_topic_score_gemma":0.0003867216,"domain_scores_codex":[0.9999473,0.00001105375,0.000005069155,0.00001079484,0.00001267263,0.00001312586],"domain_scores_gemma":[0.9999198,0.000008483913,0.00003374367,0.000005286906,0.00001349499,0.00001924951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002827965,0.0002324532,0.08117263,0.0006115626,0.0001849994,0.009614916,0.000710384,0.0002798316,0.8070934,0.003101441,0.003121555,0.09104873],"study_design_scores_gemma":[0.00074147,0.003530783,0.6074528,0.0004322008,0.0004994075,0.05622889,0.002721154,0.001637173,0.2639258,0.01243082,0.05034764,0.00005184414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846811,0.01171646,0.001324004,0.0003949252,0.00006610103,0.00002256145,0.0001071208,0.00004457146,0.001643126],"genre_scores_gemma":[0.9938703,0.003356844,0.0007849621,0.0002591376,0.00007718971,0.00001674576,0.0001160764,0.000008434193,0.001510193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364513,"threshold_uncertainty_score":0.004564703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0222701249260753,"score_gpt":0.2720392343792894,"score_spread":0.2497691094532141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}