{"id":"W4389615796","doi":"10.1128/jvi.01809-23","title":"Hepatitis C virus modified sE2 <sub>F442NYT</sub> as an antigen in candidate vaccine facilitates human immune cell activation","year":2023,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Burnet Institute","keywords":"Biology; CD86; Antigen; Immune system; CD28; Peripheral blood mononuclear cell; Molecular biology; IL-2 receptor; CD81; T cell; Antibody; Virology; Immunology; Hepatitis C virus; Virus; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009119253,0.0002528327,0.0001531801,0.00006842926,0.00005846301,0.0001640329,0.00008214414,0.0002172764,0.001192494],"category_scores_gemma":[0.00006457281,0.0000706677,0.0001380679,0.0000608229,0.00008748464,0.0001001112,0.0001444854,0.0001683558,0.0002776098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001148361,"about_ca_system_score_gemma":0.00007544681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002496732,"about_ca_topic_score_gemma":0.0003509071,"domain_scores_codex":[0.999934,0.00001484994,0.000003830568,0.00001268897,0.00001726906,0.00001741696],"domain_scores_gemma":[0.9999808,0.000003004364,0.000005085294,0.000002573369,0.000004474065,0.000003900946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007165751,0.00001529692,0.00009030661,0.00001528397,0.000002626224,0.000023186,0.000004164401,0.0001191689,0.9988571,0.0000416732,0.00002566941,0.0007338495],"study_design_scores_gemma":[0.00001303194,0.0005570633,0.001188636,0.00000371141,0.000009800809,0.0001708296,0.000008906767,0.00122648,0.9944434,0.00002284283,0.002352403,0.000002974524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957017,0.0004477325,0.002595918,0.00003264563,0.00001812792,0.00003084442,0.00008522796,0.00002570214,0.001062063],"genre_scores_gemma":[0.9953301,0.0002573952,0.002192609,0.00003166836,0.000005966036,0.00002039576,0.0001693133,0.00001150419,0.001981154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192494,"threshold_uncertainty_score":0.00398922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0289875849683622,"score_gpt":0.3377480565704881,"score_spread":0.3087604716021259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}