{"id":"W4389615885","doi":"10.34133/research.0295","title":"Activable Photodynamic DNA Probe with an “AND” Logic Gate for Precision Skin Cancer Therapy","year":2023,"lang":"en","type":"article","venue":"Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Natural Science Foundation of Hainan Province","keywords":"Photodynamic therapy; Skin cancer; Cancer; Cancer therapy; Medicine; Nanotechnology; Cancer research; Computer science; Materials science; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006515427,0.00009970038,0.0001097012,0.0001060171,0.0001790043,0.00003901927,0.0001324334,0.00009493977,0.000002383433],"category_scores_gemma":[0.00004410812,0.00006618434,0.00003542311,0.0003115417,0.0001220206,0.000005647172,0.00007426556,0.000104771,0.000001479727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001957204,"about_ca_system_score_gemma":0.00007366791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006601888,"about_ca_topic_score_gemma":0.0001487372,"domain_scores_codex":[0.9988682,0.00009650244,0.00008505911,0.0004067151,0.0002032702,0.0003402606],"domain_scores_gemma":[0.9993722,0.00003529555,0.00002774182,0.0002804743,0.0002177373,0.00006653286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006599358,0.0000383686,0.00008278197,0.0000134418,0.00002941643,0.000001549816,0.00001742304,0.00001233293,0.9612456,0.00002108488,0.0004187808,0.03745931],"study_design_scores_gemma":[0.0003742133,0.001786659,0.0005100596,0.00002570699,0.00000389629,0.00000316847,0.00007132007,0.001266987,0.9848416,0.001118097,0.009874061,0.000124161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977955,0.0002028577,0.0009647757,0.0003214388,0.000009997855,0.0005243568,0.00002024321,0.00005082392,0.0001099735],"genre_scores_gemma":[0.9897419,0.003331407,0.003802099,0.00006025617,0.00009630681,0.0001994912,0.0001160323,0.00002597154,0.002626596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03733515,"threshold_uncertainty_score":0.2698919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06480247585289668,"score_gpt":0.4302646365439388,"score_spread":0.3654621606910421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}